Immunogenetic study on the polymorphism of serum ?2-lipoproteins in mink. II. Identification of allotypes Lpm-7 and Lpm-8 and genetic control of seven markers of the Lpm system
| Autor: | D. K. Belyaev, O. K. Baranov, V. I. Yermolaev |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Immunodiffusion
Immunoelectrophoresis Biochemistry Genetic analysis Epitopes Antigen Genetic linkage biology.animal Genetics medicine Animals Mink Allele Molecular Biology Alleles Ecology Evolution Behavior and Systematics Polymorphism Genetic medicine.diagnostic_test biology General Medicine Human genetics Ploidy Lipoproteins HDL Ultracentrifugation |
| Zdroj: | Biochemical Genetics. 16:399-414 |
| ISSN: | 1573-4927 0006-2928 |
| Popis: | By means of alloimmunization of mink, two new antigens, Lpm-7 and Lpm-8, were detected in their sera. Lpm-7 and Lpm-8 allospecificities were referred to a very high density α2-lipoprotein (Lpm) by the following criteria: histochemical tests, immunoelectrophoresis, preparative ultracentrifugation, and coalescence of alloprecipitates with heteroprecipitates in double diffusion tests. Genetic analysis indicated that Lpm-7 and Lpm-8, together with the earlier described Lpm-1, Lpm-2, Lpm-3, Lpm-4, and Lpm-5, share a common immunogenetic system. Polymorphism for the seven markers is conditioned by the genetic units Lpm8, Lpm4, Lpm4, 8, Lpm4, 7, Lpm3, 4, 8, Lpm1, 8, Lpm1, 2, 7, and Lpm2, 4, 5, 7, which behave as alleles. Of these units, the latter six are probably haploid sets of closely linked genes. |
| Databáze: | OpenAIRE |
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