High-fat diet exposure increases dopamine D2 receptor and decreases dopamine transporter receptor binding density in the nucleus accumbens and caudate putamen of mice
| Autor: | Xu-Feng Huang, Timothy South |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Leptin
Male medicine.medical_specialty Nucleus accumbens Biochemistry Nucleus Accumbens Cellular and Molecular Neuroscience Mice Dopamine Internal medicine Dopamine receptor D2 medicine Animals Obesity Receptor Dopamine transporter Dopamine Plasma Membrane Transport Proteins biology Chemistry Receptors Dopamine D2 Putamen Dopaminergic Transporter General Medicine Dietary Fats Immunohistochemistry Diet Mice Inbred C57BL Endocrinology biology.protein Autoradiography medicine.drug |
| Zdroj: | Neurochemical research. 33(3) |
| ISSN: | 0364-3190 |
| Popis: | This experiment examined dopamine D2 receptor and its transporter (DAT) density in mice fed a high-fat or low-fat diet for twenty days as well as fed twenty days of high-fat diet then changed to low-fat diet for one and seven days. Quantitative autoradiography revealed that twenty days of high-fat diet consumption significantly increased D2 receptor and decreased DAT density in the dorsal and ventral parts of the caudal caudate putamen (D2: 32% and 35% respectively, DAT: 33.3% and 28.8% respectively) compared with low-fat diet. High-fat feeding also increased D2 binding in the nucleus accumbens shell (36%). D2 receptor and DAT density remained unchanged following reversal of the diets from high-fat to low-fat diet. The high-fat diet induced increase of D2 receptor and decrease of DAT binding may have occurred due to defensive control over dopaminergic activity in response to a positive energy balance. |
| Databáze: | OpenAIRE |
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