Occult blood flow patterns distal to an occluded artery in acute ischemic stroke
| Autor: | Jonathan M. Coutinho, Henk A. Marquering, Charles B. L. Majoie, Wera S. Niekolaas, Ed van Bavel, Manon L. Tolhuisen, Bettine G. van Willigen, Nerea Arrarte Terreros, Josje Brouwer, Ludo F. M. Beenen |
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| Přispěvatelé: | Eindhoven MedTech Innovation Center, Cardiovascular Biomechanics, Graduate School, Radiology and Nuclear Medicine, Biomedical Engineering and Physics, Amsterdam Neuroscience - Neurovascular Disorders, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Brain Imaging, Neurology, ACS - Pulmonary hypertension & thrombosis |
| Jazyk: | angličtina |
| Předmět: |
Male
medicine.medical_specialty Computed Tomography Angiography Acute ischemic stroke Clinical Neurology Collateral Circulation Ischemic Stroke/diagnostic imaging Internal medicine dynamic CTA medicine blood flow quantification Humans In patient Thrombus Ischemic Stroke Aged business.industry Original Articles Blood flow Cerebral Arteries Middle Aged medicine.disease Collateral circulation Arterial occlusion Occult Cerebral Angiography medicine.anatomical_structure Cerebral Arteries/diagnostic imaging Neurology thrombus permeability Cardiology Neurology (clinical) Cardiology and Cardiovascular Medicine business Blood Flow Velocity Artery |
| Zdroj: | Journal of Cerebral Blood Flow and Metabolism, 42(2), 292-302. Nature Publishing Group PubMed Central ORCID Microsoft Academic Graph Journal of Cerebral Blood Flow & Metabolism Journal of cerebral blood flow and metabolism, 42(2), 292-302. Nature Publishing Group |
| ISSN: | 1559-7016 0271-678X |
| DOI: | 10.1177/0271678x211044941 |
| Popis: | Residual blood flow distal to an arterial occlusion in patients with acute ischemic stroke (AIS) is associated with favorable patient outcome. Both collateral flow and thrombus permeability may contribute to such residual flow. We propose a method for discriminating between these two mechanisms, based on determining the direction of flow in multiple branches distal to the occluding thrombus using dynamic Computed Tomography Angiography (dynamic CTA). We analyzed dynamic CTA data of 30 AIS patients and present patient-specific cases that identify typical blood flow patterns and velocities. We distinguished patterns with anterograde (N = 10), retrograde (N = 9), and both flow directions (N = 11), with a large variability in velocities for each flow pattern. The observed flow patterns reflect the interplay between permeability and collaterals. The presented method characterizes distal flow and provides a tool to study patient-specific distal tissue perfusion. |
| Databáze: | OpenAIRE |
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