Skeletal Muscle Ventricles for Total Heart Replacement
| Autor: | Hiroshi Niinami, David E. Anderson, Larry W. Stephenson, P Samet, Robert L. Hammond, Ali D. Spanta, Alberto Pochettino, Charles R. Bridges, E Hohenhaus, Stanley Salmons |
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| Rok vydání: | 1990 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Electric Stimulation Therapy Stroke work Dogs Left latissimus dorsi muscle Internal medicine medicine Animals Cardiac Surgical Procedures Left ventricular stroke work business.industry Muscles Myocardium Skeletal muscle Heart Stroke Volume Anatomy Adaptation Physiological medicine.anatomical_structure Ventricle Physical Endurance Cardiology Surgery business Research Article |
| Zdroj: | Annals of Surgery. 212:345-352 |
| ISSN: | 0003-4932 |
| DOI: | 10.1097/00000658-199009000-00013 |
| Popis: | Skeletal muscle ventricles (SMV) were constructed from canine left latissimus dorsi muscle. The animals were divided into three groups: group A (n = 5), SMVs rested 4 weeks without electrical conditioning; group B (n = 6), SMVs rested 4 weeks and then electrically conditioned for 6 weeks; group C (n = 5), SMVs rested 18 weeks without electrical conditioning. At the end of each protocol, the SMVs were acutely tested by connecting them to a mock-circulation device. The SMVs in group C developed stroke work at physiologic preloads superior to any previously reported, as high as 194% of left ventricular stroke work at afterloads of 80 mmHg. The SMVs in group B developed work outputs equivalent to 53% of the left ventricle, which is still more than four times that of the right ventricle. The results show that it is possible to harvest sufficient work from skeletal muscle ventricles to fully replace cardiac function at physiologic preloads. |
| Databáze: | OpenAIRE |
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