Relationship between circulating tumor necrosis factor system and bone mass before and after estrogen plus progestogen therapy
| Autor: | Chang Suk Suh, Sung Wook Chun, Seung Yup Ku, Young Min Choi, Jung Gu Kim, Hoon Kim |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment Bone remodeling Basal (phylogenetics) Bone Density Internal medicine medicine Humans Receptors Tumor Necrosis Factor Type II Longitudinal Studies Lymphotoxin-alpha Osteoporosis Postmenopausal Aged Bone mineral Progestogen Tumor Necrosis Factor-alpha business.industry Estrogen Replacement Therapy Obstetrics and Gynecology Estrogens Middle Aged medicine.disease Menopause Endocrinology Receptors Tumor Necrosis Factor Type I Estrogen Female Tumor necrosis factor alpha Progestins business Body mass index |
| Zdroj: | Menopause. 16:534-538 |
| ISSN: | 1072-3714 |
| DOI: | 10.1097/gme.0b013e3181920c77 |
| Popis: | OBJECTIVE The aim of his study was to investigate the relationship between the circulating tumor necrosis factor (TNF) system and bone mineral density (BMD) before and after estrogen plus progestogen therapy (EPT). METHODS Serum levels of TNF-alpha, TNF-beta, soluble TNF receptor (sTNFR) 1, sTNFR2, and bone turnover markers and BMDs at the lumbar spine and proximal femur were measured in 192 postmenopausal Korean women. Among all women, 70 were treated with sequential EPT for 1 year. RESULTS BMDs at all skeletal sites and bone turnover markers were not correlated with serum TNF and sTNFR. After adjustment for age, years since menopause, and body mass index, serum TNF-beta levels were significantly lower in osteoporotic women than in normal women, whereas serum levels of TNF-alpha and sTNFR did not differ among normal, osteopenic, and osteoporotic postmenopausal women. After 6 months of EPT, serum TNF-beta levels increased significantly (P < 0.05), whereas serum TNF-alpha, sTNFR1, and sTNFR2 levels were unchanged. The 1-year changes in BMD at the lumbar spine and proximal femur after EPT were not correlated with the basal levels of serum TNF-alpha and sTNFR and their changes 6 months after EPT. CONCLUSIONS In the circulating TNF system, only serum TNF-beta levels were lower in osteoporotic postmenopausal women compared with normal postmenopausal women and increased after EPT, but changes in circulating TNF and sTNFR after EPT had no association with changes in bone markers and BMD. The circulating TNF system may not be clinically useful for predicting BMD and bone response after EPT. |
| Databáze: | OpenAIRE |
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