| Autor: |
Liam A. McLean, Allan J. B. Watson |
| Přispěvatelé: |
EPSRC, University of St Andrews. School of Chemistry, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
LAM thanks the EPSRC (grant number EP/S027165/1) for postdoctoral funding. An alternative synthesis of cycloalkyl-substituted CPA catalysts is reported. A Negishi coupling offers improved yields and purity of the necessary 1,3,5-tri(cycloalkyl)benzenes. Limitations in the use of commercial organozinc reagents have been identified and a robust procedure for the preparation of these reagents is detailed. Similarly, a robust procedure for the key Kumada coupling is also provided. The route is demonstrated by preparation of three different tri(cycloalkyl)aryl-substituted CPAs and the utility of these catalysts in asymmetric protonation reactions is shown. Publisher PDF |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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