1A-779 attenuates angiotensin-(1–7) depressor response in salt-induced hypertensive rats
| Autor: | Marcus Walton, Danita Eatman, Mohamed A. Bayorh, Nerimiah Emmett, Robin R. Socci, Myrtle Thierry-Palmer |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Time Factors Physiology Thromboxane Blood Pressure Vasodilation Prostacyclin 6-Ketoprostaglandin F1 alpha Nitric Oxide Biochemistry Dinoprostone Nitric oxide Thromboxane A2 Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Rats Inbred SHR Internal medicine medicine Animals Cyclic GMP Rats Inbred Dahl Angiotensin II Body Weight Antagonist Prostanoid Epoprostenol Peptide Fragments Rats Thromboxane B2 Blood pressure chemistry Hypertension cardiovascular system Salts Angiotensin I Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Peptides. 23:57-64 |
| ISSN: | 0196-9781 |
| Popis: | Chronic infusion of angiotensin-(1–7) [Ang-(1–7)] lowers blood pressure in salt-induced and spontaneously hypertensive (SHR) rats. In the present study, we have examined the acute effect of Ang-(1–7) in salt-induced hypertension using Dahl salt-sensitive rats placed on low (0.3%) or high (8.0% NaCl) salt diets for 2 weeks. Rats fed a high salt diet showed a greater rise in BP than those fed a low salt diet. Ang-(1–7) (24 μg/kg) reduced mean arterial pressure (MAP), enhanced the release of prostacyclin and nitric oxide, and suppressed thromboxane A 2 levels. A-779 (48 μg/kg, i.v), a selective Ang-(1–7) antagonist, partially blocked these effects of Ang-(1–7). The Ang-(1–7)-induced depressor response observed in these animals was related to an increase in vasodilatory prostanoids, a decrease in the constrictor prostanoid thromboxane A 2 , and an increase in nitric oxide levels in both plasma and isolated aortic rings. |
| Databáze: | OpenAIRE |
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