A primary retroperitoneal anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with tumor thrombosis
| Autor: | Wei Liu, Xiao-chao Guo, Yinmo Yang, Wei Wang, Xiaodong Tian, Jisong Li, Ke Wang, Mangju Wang, Lin Nong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
tumor thrombosis
Pathology medicine.medical_specialty medicine.medical_treatment Case Report 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Biopsy Anaplastic lymphoma kinase Medicine Pharmacology (medical) Anaplastic large-cell lymphoma Chemotherapy medicine.diagnostic_test business.industry Abdominal distension anaplastic lymphoma kinase medicine.disease Abdominal mass Lymphoma Oncology anaplastic large cell lymphoma 030220 oncology & carcinogenesis Differential diagnosis medicine.symptom business primary retroperitoneal lymphoma |
| Zdroj: | OncoTargets and therapy |
| ISSN: | 1178-6930 |
| Popis: | Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) is a T cell subtype of non-Hodgkin's lymphoma (NHL). Typically, lymphoma rarely infiltrates vascular structure. In this article, we present a case of retroperitoneal ALK-positive ALCL with splenic venous tumor thrombosis. A 62-year-old patient presented to our institute with the symptoms of epigastric pain, abdominal distension, and reduced bowel movement. Physical examination indicated no enlarged peripheral lymph nodes or abdominal mass. Laboratory workup revealed granulocytosis, abnormal coagulation function, and normal level of lactic dehydrogenase (LDH). Contrast-enhanced computed tomography (CT) showed a retroperitoneal mass with involvement of pancreas and duodenum and formation of splenic venous tumor thrombus. Ultrasonography-guided retroperitoneal lesion biopsy confirmed the diagnosis of ALK-positive ALCL. The patient was able to tolerate oral intake after two cycles of chemotherapy and showed no sign of lymphoma by positron emission tomography (PET)-CT after the fourth cycle of chemotherapy. In spite of its rarity, lymphoma should be taken into account as a differential diagnosis of other malignancies with tumor thrombosis. |
| Databáze: | OpenAIRE |
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