New furanoditerpenoids from Croton jatrophoides
| Autor: | Sandra Apers, Arnold J. Vlietinck, Musa Chacha, Zakaria H. Mbwambo, Jan Fraanje, Modest C. Kapingu, Luc Pieters, Filip Lemière, Joseph J. Magadula, Kees Goubitz, Mainen M. Moshi, K Foubert, René Peschar |
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| Přispěvatelé: | HIMS Other Research (FNWI) |
| Rok vydání: | 2009 |
| Předmět: |
Diffraction
Stereochemistry Chemical structure Pharmaceutical Science Crystal structure Plant Roots Tanzania Analytical Chemistry chemistry.chemical_compound Isomerism Drug Discovery Furans Biology Pharmacology Molecular Structure Isoteucvin Plant Extracts Pharmacology. Therapy Organic Chemistry Absolute configuration Croton jatrophoides Complementary and alternative medicine chemistry Molecular Medicine Jatrophoidin Croton Diterpene Diterpenes |
| Zdroj: | Planta medica: natural products and medicinal plant research Planta Medica, 75(3), 262-267. Georg Thieme Verlag |
| ISSN: | 0032-0943 |
| DOI: | 10.1055/s-0028-1088383 |
| Popis: | Four furanoditerpenoids were isolated from roots of Croton jatrophoides (Euphorbiaceae) collected in Tanzania. In addition to the known compounds penduliflaworosin and teucvin (mallotucin A), a new teucvin isomer, which was named isoteucvin, and a furanoditerpenoid with a new skeleton, for which the name jatrophoidin was adopted, were isolated. Their structures were elucidated by spectroscopic methods such as ESI-MS and NMR, including H-1-, C-13-, and two-dimensional NMR. The crystal structures of isoteucvin and jatrophoidin were solved using single-crystal X-ray diffraction, by which we also established the absolute configuration of jatrophoidin. The refined crystal structure of isoteucvin has the same (absolute) configuration as jatrophoidin, although the X-ray diffraction data of isoteucvin were not conclusive with respect to the absolute configuration. |
| Databáze: | OpenAIRE |
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