Relationship between apoptosis regulator proteins (bcl-2 and p53) and Gleason score in prostate cancer
| Autor: | Akif Ciftcioglu, Sargin Fc, Mehmet Baykara, Karaburun Paker S, Kilicarslan B, Tibet Erdogru, Oztekin S |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Oncology
PCA3 Male Cancer Research Programmed cell death medicine.medical_specialty Apoptosis Adenocarcinoma urologic and male genital diseases Pathology and Forensic Medicine Immunoenzyme Techniques Prostate cancer Internal medicine Biopsy medicine Humans Intermediate Grade Aged Neoplasm Staging Retrospective Studies Aged 80 and over medicine.diagnostic_test Apoptosis Regulator business.industry Prostatic Neoplasms General Medicine Middle Aged medicine.disease Prognosis Neoplasm Proteins Proto-Oncogene Proteins c-bcl-2 Disease Progression Immunohistochemistry Tumor Suppressor Protein p53 business |
| Zdroj: | Pathology oncology research : POR. 7(3) |
| ISSN: | 1219-4956 |
| Popis: | Cellular proliferation programmed cell death (apoptosis) are associated with tumor growth in general, and prostate cancer growth in particular. The aim of this study was to examine the expression of the apoptosis regulating genes bcl-2 and p53 and Gleason score in core needle biopsy specimens of prostate cancer using immunohistochemistry. We studied bcl-2 and p53 expression in 12 cases of low grade (Gleason score 2–5), 12 cases of intermediate grade (Gleason score 6–7) and 8 cases of high grade (Gleason score 8–10) prostate cancer. Overexpression of bcl-2 was noted in 3 of 32 patients (9.32%). One of them was high grade; others were intermediate grades. Expression of p53 was observed in 3 of low grades; others were high grade. The statistical analysis of present data suggest that there is no significant relation between p53 and bcl-2 expression and Gleason score in prostate cancer. |
| Databáze: | OpenAIRE |
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