IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis
| Autor: | Phillip M. Brailey, Richard B. Jones, Rui André Saraiva Raposo, Szu-Han Huang, Paul M. Zdinak, Vinicius D. Cabido, Dominic Paquin-Proulx, Greta A. Beckerle, Miguel de Mulder Rougvie, Allison S. Thomas, Douglas F. Nixon |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
CD4-Positive T-Lymphocytes
0301 basic medicine 030106 microbiology HIV Infections Biology Virus 03 medical and health sciences Immune system Antigen In vivo Humans Antibody-Dependent Cell Cytotoxicity General Medicine Antigens Differentiation Virology Transmembrane protein 3. Good health Cytolysis 030104 developmental biology Anti-Retroviral Agents Immunology HIV-1 biology.protein Antibody Ex vivo Research Article |
| Zdroj: | JCI Insight. 2 |
| ISSN: | 2379-3708 |
| DOI: | 10.1172/jci.insight.85811 |
| Popis: | HIV-1 persistence in latent reservoirs during antiretroviral therapy (ART) is the main obstacle to virus eradication. To date, there is no marker that adequately identifies latently infected CD4+ T cells in vivo. Using a well-established ex vivo model, we generated latently infected CD4+ T cells and identified interferon-induced transmembrane protein 1 (IFITM1), a transmembrane antiviral factor, as being overexpressed in latently infected cells. By targeting IFITM1, we showed the efficient and specific killing of a latently infected cell line and CD4+ T cells from ART-suppressed patients through antibody-dependent cytolysis. We hypothesize that IFITM1 could mark natural reservoirs, identifying an immune target for killing of latently infected cells. These novel insights could be explored to develop clinical therapeutic approaches to effectively eradicate HIV-1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|