Repression of Hyphal Proteinase Expression by the Mitogen-Activated Protein (MAP) Kinase Phosphatase Cpp1p of Candida albicans Is Independent of the MAP Kinase Cek1p
| Autor: | Csilla Csank, Martin Röllinghoff, Malcolm Whiteway, Katrin Sprösser, David Y. Thomas, Klaus Schröppel |
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| Rok vydání: | 2000 |
| Předmět: |
Mitogen-Activated Protein Kinase 3
Immunology Mutant Phosphatase Protein tyrosine phosphatase Microbiology Fungal Proteins Candida albicans Aspartic Acid Endopeptidases pharmaceutical RNA Messenger Protein kinase A genome biology Kinase fungi biology.organism_classification Molecular biology DNA-Binding Proteins Repressor Proteins Infectious Diseases MAP kinase phosphatase Parasitology Fungal and Parasitic Infections Mitogen-Activated Protein Kinases Protein Tyrosine Phosphatases Transcription Factors |
| Zdroj: | Infection and Immunity. 68:7159-7161 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.68.12.7159-7161.2000 |
| Popis: | Cpp1p is a putative mitogen-activated protein (MAP) kinase phosphatase that suppresses Candida albicans hyphal formation at 25°C through its probable substrate, the Cek1p filamentation MAP kinase. Here we report that expression of the serum-induced genes SAP4-6 and HYR1 increased several fold in hyphal forms of a cpp1/cpp1 null mutant, while the rate and extent of hyphal development up to 5 h were normal. Therefore, we provide evidence that Cpp1p represses hyphal gene expression by acting through a Cek1p-independent mechanism. SAP4-6 and HYR1 transcripts were undetectable in a null mutant of another key regulator of filamentation, Efg1p; thus, Efg1p and Cpp1p oppose each other during the expression of these genes in hyphal forms. |
| Databáze: | OpenAIRE |
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