Role of parathyroid hormone in regeneration of irradiated bone in a murine model of mandibular distraction osteogenesis
| Autor: | Peter A. Felice, Noah S. Nelson, Stephen Y. Kang, Douglas B. Chepeha, Sagar S. Deshpande, Steven R. Buchman, Jose J. Rodriguez, Alexis Donneys, Alexander R. Zheutlin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Bone Regeneration medicine.medical_treatment Mandibular Osteotomy Osteogenesis Distraction Parathyroid hormone 030209 endocrinology & metabolism Mandible 03 medical and health sciences Random Allocation 0302 clinical medicine Reference Values Internal medicine medicine Animals Bone regeneration Immature Bone business.industry Regeneration (biology) Biopsy Needle Immunohistochemistry Rats Radiation therapy Disease Models Animal Radiation Injuries Experimental medicine.anatomical_structure Endocrinology Otorhinolaryngology Osteoradionecrosis Parathyroid Hormone Rats Inbred Lew 030220 oncology & carcinogenesis Osteocyte Distraction osteogenesis business |
| Zdroj: | Headneck. 39(3) |
| ISSN: | 1097-0347 |
| Popis: | Background The purpose of this study was to measure the histologic and histomorphometric effects of parathyroid hormone (PTH) treatment on irradiated bone undergoing distraction osteogenesis (DO). Methods Thirty-four rats were divided into 3 groups. The control group underwent DO and the radiation control group underwent radiotherapy (RT) before DO. The PTH group underwent RT and received PTH during DO. Quantitative histology and histomorphometry were performed. Results RT resulted in a depletion of osteocytes and increase in empty lacunae. Treatment with PTH resulted in an increase in osteocyte counts and decrease in empty lacunae (p < .05), restoring osteocytes to levels seen in nonradiated bone (p = .121). RT decreased bone volume to tissue volume (BV-TV) ratio and increased osteoid volume to tissue volume (OV-TV) ratio, signifying increased immature bone formation. PTH treatment restored OV-TV ratio to that observed in nonradiated bone. Conclusion PTH treatment of irradiated bone enhanced bone regeneration and restored osteocyte counts and OV-TV ratio to levels comparable to nonradiated bone. © 2016 Wiley Periodicals, Inc. Head Neck 39: 464–470, 2017 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text