Appraisal of the PIBD-classes Criteria: A Multicentre Validation

Autor:	Raffi Lev Tzion, Dan Turner, Liron Birimberg-Schwartz, Manar Matar, Oren Ledder, Anne M. Griffiths, Richard K Russell, Eyal Shteyer, Micol Sonnino, Esther Orlanski-Meyer, Johanna C. Escher, Amit Assa
Přispěvatelé:	Pediatrics
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Male Canada Crohn's disease medicine.medical_specialty Adolescent business.industry Gastroenterology Age at diagnosis Retrospective cohort study General Medicine Inflammatory Bowel Diseases medicine.disease Inflammatory bowel disease Ulcerative colitis Derivation cohort Cohort Studies Child Preschool Internal medicine medicine Humans Female Israel Child business Retrospective Studies
Zdroj:	Journal of Crohn's and Colitis, 14(12), 1672-1679. Oxford University Press
ISSN:	1873-9946
Popis:	IntroductionThe PIBD-classes criteria were developed to standardise the classification of children with inflammatory bowel disease [IBD], from Crohn’s disease [CD], through IBD-unclassified [IBD-U], to typical ulcerative colitis [UC]. We aimed to further validate the criteria and to explore possible modifications.MethodsThis was a multicentre retrospective cohort study of children diagnosed with IBD with at least 1 year of follow-up. Clinical, radiological, endoscopic, and histological data were recorded at diagnosis and latest follow-up, as well as the 23 items of the PIBD-classes criteria. The PIBD-classes criteria were assessed for redundant items, and a simplified algorithm was proposed and validated on the original derivation cohort from which the PIBD-classes algorithm was derived.ResultsOf the 184 included children [age at diagnosis 13 ± 3 years, 55% males], 122 [66%] were diagnosed by the physician with CD, 17 [9%] with IBD-U, and 45 [25%] with UC. There was high agreement between physician-assigned and PIBD-classes generated diagnosis for CD [93%; eight patients moved to IBD-U] and for UC [84%; six moved to IBD-U and one to CD]. A simplified version of the algorithm with only 19 items is suggested, with comparable performance to the original algorithm [81% sensitivity and 81% specificity vs 78% and 83% for UC; and 79% and 95% vs 80% and 95% for CD, respectively].ConclusionsThe PIBD-classes algorithm is a useful tool to facilitate standardised objective classification of IBD subtypes in children. A modified version of the PIBD-classes maintains accuracy of classification with a simplified algorithm.
Databáze:	OpenAIRE
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