Cytologic Features Useful for Distinguishing Small Cell From Non–Small Cell Carcinoma in Bronchial Brush and Wash Specimens
| Autor: | Joyce A. D’Antonio, Diana L. Nassar, Stephen S. Raab, Charles D. Sturgis |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Lung Neoplasms Cytodiagnosis Cell Bronchi Bronchoalveolar Lavage Small-cell carcinoma Specimen Handling Diagnosis Differential Salt-and-pepper chromatin Carcinoma Non-Small-Cell Lung Cytology medicine Carcinoma Humans Single-Blind Method Carcinoma Small Cell Aged Retrospective Studies Aged 80 and over Cell Nucleus business.industry General Medicine Middle Aged medicine.disease Chromatin Logistic Models medicine.anatomical_structure Cytopathology Cytoplasm Female business Bronchoalveolar Lavage Fluid |
| Zdroj: | American Journal of Clinical Pathology. 114:197-202 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1309/8mqg-6xek-3x9l-a9xu |
| Popis: | One blinded observer (C.D.S.) retrospectively reviewed 76 previously diagnosed and biopsy-confirmed malignant bronchial brush and wash specimens, 46 non-small cell and 30 small cell carcinomas, obtained from 55 patients. Each case was scored for the presence or absence of 36 standard criteria (architectural, cytoplasmic, and nuclear). Logistic regression analysis was used to determine which criteria were most useful for separating small cell from non-small cell lesions. Although no single criterion displayed 100% sensitivity and specificity for small cell cancer, univariate statistical analysis indicated that 3 individual criteria (nuclear molding, finely granular or "salt and pepper" chromatin, and scant delicate cytoplasm) were more than 90% sensitive and specific in cases of small cell carcinoma. The presence of nuclear molding alone provided the best fit for the logistic regression model. When nuclear molding was present, the odds of a small cell diagnosis increased more than 300-fold. Nuclear molding, finely granular or salt and pepper chromatin, and scant, delicate cytoplasm are the 3 most sensitive and specific cytomorphologic features traditionally used to separate small cell from non-small cell carcinoma. Nuclear molding alone represents the most significant cytomorphologic feature for distinguishing between these malignant lesions. |
| Databáze: | OpenAIRE |
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