Evolution of Spatially Coexpressed Families of Type-2 Vomeronasal Receptors in Rodents
| Autor: | Simona Francia, Lucia Silvotti, François Catzeflis, Roberto Tirindelli, Riccardo Percudani, Filippo Ghirardi |
|---|---|
| Přispěvatelé: | Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226 |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Subfamily
Lineage (genetic) Vomeronasal organ Zoology Rodentia vomeronasal Major histocompatibility complex phylogeny Evolution Molecular Major Histocompatibility Complex Mice 03 medical and health sciences 0302 clinical medicine Phylogenetics evolution Genetics Animals Receptor Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences biology Phylogenetic tree Receptors Pheromone chemosensory Evolutionary biology Sex pheromone rodents biology.protein Vomeronasal Organ [SDE.BE]Environmental Sciences/Biodiversity and Ecology pheromones 030217 neurology & neurosurgery Research Article |
| Zdroj: | Genome Biology and Evolution Genome Biology and Evolution, 2015, 7 (1), pp.272-285. ⟨10.1093/gbe/evu283⟩ Genome Biology and Evolution, Society for Molecular Biology and Evolution, 2015, 7 (1), pp.272-285. ⟨10.1093/gbe/evu283⟩ |
| ISSN: | 1759-6653 |
| DOI: | 10.1093/gbe/evu283⟩ |
| Popis: | International audience; The vomeronasal organ (VNO) is an olfactory structure for the detection of pheromones. VNO neurons express three groups of unrelated G-protein-coupled receptors. Type-2 vomeronasal receptors (V2Rs) are specifically localized in the basal neurons of the VNO and are believed to sense protein pheromones eliciting specific reproductive behaviors. In murine species, V2Rs are organized into four families. Family-ABD V2Rs are expressed monogenically and coexpress with family-C V2Rs of either subfamily C1 (V2RC1) or subfamily C2 (V2RC2), according to a coordinate temporal diagram. Neurons expressing the phylogenetically ancient V2RC1 coexpress family-BD V2Rs or a specific group of subfamily-A V2Rs (V2RA8-10), whereas a second neuronal subset (V2RC2-positive) coexpresses a recently expanded group of five subfamily-A V2Rs (V2RA1-5) along with vomeronasal-specific Major Histocompatibility Complex molecules (H2-Mv). Through database mining and Sanger sequencing, we have analyzed the onset, diversification, and expansion of the V2R-families throughout the phylogeny of Rodentia. Our results suggest that the separation of V2RC1 and V2RC2 occurred in a Cricetidae ancestor in coincidence with the evolution of the H2-Mv genes; this phylogenetic event did not correspond with the origin of the coexpressing V2RA1-5 genes, which dates back to an ancestral myomorphan lineage. Interestingly, the evolution of receptors within the V2RA1-5 group may be implicated in the origin and diversification of some of the V2R putative cognate ligands, the exocrine secreting peptides. The establishment of V2RC2, which probably reflects the complex expansion and diversification of family-A V2Rs, generated receptors that have probably acquired a more subtle functional specificity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|