Inflammatory cytokines and combined biomarker panels in pancreatic ductal adenocarcinoma: Enhancing diagnostic accuracy

Autor: Yandiswa Y Yako, J. Devar, Martin Smith, Deirdre Kruger, Nicola Lahoud
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Oncology
Male
endocrine system diseases
Physiology
Logistic regression
Pathology and Laboratory Medicine
Biochemistry
0302 clinical medicine
Immune Physiology
Adenocarcinomas
Medicine and Health Sciences
Medicine
Bile
Prospective Studies
Prospective cohort study
Immune Response
Innate Immune System
Multidisciplinary
Common bile duct
Jaundice
Middle Aged
Body Fluids
Neoplasm Proteins
medicine.anatomical_structure
Liver
030220 oncology & carcinogenesis
Biomarker (medicine)
Cytokines
Female
medicine.symptom
Anatomy
Research Article
Carcinoma
Pancreatic Ductal
Adult
medicine.medical_specialty
Pancreatic ductal adenocarcinoma
Science
Immunology
Carcinomas
Proinflammatory cytokine
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
Carcinoma
Cancer Detection and Diagnosis
Biomarkers
Tumor
Humans
Aged
Inflammation
business.industry
Biology and Life Sciences
Cancers and Neoplasms
Bilirubin
Molecular Development
medicine.disease
digestive system diseases
Pancreatic Neoplasms
030104 developmental biology
Immune System
Biliary System
Bile Ducts
business
Biomarkers
Developmental Biology
Zdroj: PLoS ONE, Vol 14, Iss 8, p e0221169 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: BackgroundEarly diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenged by the absence of accurate early diagnostic and prognostic biomarkers. CA19-9 is the established, diagnostic tumour marker in PDAC, despite its limitations. Effective primary screening using circulating biomarker panels have only been considered in a handful of studies and we investigated whether combinations of inflammatory cytokines and angiogenic factors in multivariate logistic models could facilitate earlier diagnosis in our South African setting.MethodsPlasma levels of 38 cytokines and angiogenic factors were measured in 131 Black South African patients, 85 with PDAC, 25 with benign biliary pathology (BBP) and 21 benign non-HPB controls (BC), by use of human magnetic multiplex screening assays. Multivariate biomarker panels were developed by identifying the top performing biomolecules from univariate logistic regression. Receiver-operator characteristic (ROC) curves and area under the ROC curve (AUC) are reported.ResultsClassification modelling to distinguish PDAC patients from BC showed that a panel of CA19-9 and CXCL10 (IP-10) demonstrated improved diagnostic power over CA19-9 alone (AUC = 0.977 vs. AUC = 0.807, p-value = 0.001). A combined panel including age, BMI and IL-15 showed significant diagnostic power in discriminating PDAC from BBP (AUC = 0.952, p < 0.0001). Finally, a combined panel of IL-8, IL-15 and gender demonstrated diagnostic accuracy (AUC = 0.830, p < 0.0001) in distinguishing PDAC in the presence of jaundice from benign controls with either jaundice, choledocholithiasis or common bile duct injury.ConclusionsCombined biomarker panels improve diagnostic accuracy in PDAC. In addition to CA19-9, cytokines CXCL10, IL-8 and IL-15 are strong additions to diagnostic biomarker panels in PDAC in Black South Africans.
Databáze: OpenAIRE
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