Hyperbaric oxygen therapy improves spatial learning and memory in a rat model of chronic traumatic brain injury
| Autor: | Keith Van Meter, Robert J. Sutherland, Christopher Kriedt, Paul G. Harch |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Traumatic brain injury Rat model Post injury Hyperbaric oxygen Memory Untreated control Conditioning Psychological medicine Animals Hippocampus (mythology) Rats Long-Evans Molecular Biology Hyperbaric Oxygenation Behavior Animal General Neuroscience Recovery of Function medicine.disease Rats Surgery Disease Models Animal medicine.anatomical_structure Brain Injuries Cerebrovascular Circulation Space Perception Anesthesia Chronic Disease Spatial learning Neurology (clinical) Psychology Developmental Biology Blood vessel |
| Zdroj: | Brain Research. 1174:120-129 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2007.06.105 |
| Popis: | In the present experiment we use a rat model of traumatic brain injury to evaluate the ability of low-pressure hyperbaric oxygen therapy (HBOT) to improve behavioral and neurobiological outcomes. The study employed an adaptation of the focal cortical contusion model. 64 Male Long-Evans rats received unilateral cortical contusion and were tested in the Morris Water Task (MWT) 31-33 days post injury. Rats were divided into three groups: an untreated control group (N=22), an HBOT treatment group (N=19) and a sham-treated normobaric air group (N=23). The HBOT group received 80 bid, 7 days/week 1.5 ATA/90-min HBOTs and the sham-treated normobaric air group the identical schedule of air treatments using a sham hyperbaric pressurization. All rats were subsequently retested in the MWT. After testing all rats were euthanized. Blood vessel density was measured bilaterally in hippocampus using a diaminobenzadine stain and was correlated with MWT performance. HBOT caused an increase in vascular density in the injured hippocampus (p |
| Databáze: | OpenAIRE |
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