Comparison and Impact of The Short-Term Use of Some Non-Aspirin NSAIDs on Bleeding Time of Mice
| Autor: | Yedy P Sukmawan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Ketoprofen
Male medicine.medical_specialty Bleeding Time Hemorrhage Piroxicam Gastroenterology Mice Diclofenac Bleeding time Internal medicine medicine Animals Acetaminophen Pharmacology medicine.diagnostic_test business.industry Anti-Inflammatory Agents Non-Steroidal Hematology Ibuprofen Ketorolac Meloxicam Celecoxib Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiovascularhematological agents in medicinal chemistry. 16(2) |
| ISSN: | 1875-6182 |
| Popis: | Background Non-Steroidal Anti Inflammation Drugs (NSAIDs) have shown effectivity in pain relief and are the most prescribed around the world. However, NSAIDs impair hematological aspects that may lead to the life-threatening events. Objective The objective of the study is to determine the comparison and impact of the short-term use of some non-aspirin NSAIDs on bleeding time. Method We have 10 animals group. Each group contains 4 animals. Normal group, ketoprofen (0.26 mg/ 20 g BW of mice twice daily), ketorolac (0.078 mg/ 20 g BW of mice twice daily), diclofenac (0.13 mg/ 20 g BW of mice twice daily), piroxicam (0.052 mg/ 20 g BW of mice once daily), mefenamic acid (1.3 mg/ 20 g BW of mice thrice daily), meloxicam (0.039 mg/ 20 g BW of mice once daily), celecoxib (0.52 mg/ 20 g BW of mice once daily), ibuprofen (1.04 mg/ 20 g BW of mice thrice daily) and paracetamol group (1.3 mg/ 20 g BW of mice thrice daily). The treatment length is 5 days. Bleeding time determination was conducted one hour after the last treatment. Results All test group showed an elevation of the bleeding time by 59.78%, 156.50%, 108.73%, 99.96%, 22.59%, 85.46%, 69.66%, 42.24%, and 45.08% for meloxicam, ketoprofen, ketorolac, diclofenac sodium, paracetamol, piroxicam, mefenamic acid, ibuprofen and celecoxib than normal groups, respectively. Ketoprofen gives the highest bleeding time elevation. Conclusion Ketoprofen gives the highest bleeding time elevation while paracetamol gives the lowest bleeding time elevation. |
| Databáze: | OpenAIRE |
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