Meteorin-like/Meteorin-β Is a Novel Immunoregulatory Cytokine Associated with Inflammation
| Autor: | Irina Ushach, Gerardo Arrevillaga-Boni, Egest J. Pone, Gina N. Heller, Jovani Catalan-Dibene, Albert Zlotnik, Peter Hevezi, Marcela Hernandez-Ruiz |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Lipopolysaccharides Chemokine medicine.medical_treatment Knockout Immunology Inflammation Inbred C57BL Article Sepsis Immunomodulation 03 medical and health sciences Mice Cytokines metabolism In vivo medicine Immunology and Allergy Animals Humans 2.1 Biological and endogenous factors Nerve Growth Factors Aetiology Gene Skin Mice Knockout Mucous Membrane biology Chemistry Animal Macrophages Inflammatory and immune system medicine.disease Cell biology Mice Inbred C57BL Disease Models Animal 030104 developmental biology Cytokine medicine.anatomical_structure Infectious Diseases Disease Models biology.protein Cytokines Bone marrow medicine.symptom |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950), vol 201, iss 12 |
| Popis: | We have described a novel cytokine encoded by a gene called Meteorin-like (Metrnl). Metrnl is a small (∼28 kDa) secreted protein expressed by activated macrophages and barrier tissues (mucosa and skin). Metrnl production by bone marrow macrophages is induced by several cytokines including TNF-α, IL-17α, IL-12, and IL-4 and inhibited by IFN-γ and TGF-β. Metrnl expression in macrophages is also induced by LPS, and its levels in circulation are associated with inflammatory responses in vivo. Furthermore, Metrnl regulates the production of several cytokines and chemokines in macrophages. We have produced a Metrnl−/− mouse, which is viable and shows normal development. However, it exhibits dysregulated cytokine production, alterations in IgG production, and is highly susceptible to LPS in a sepsis model. Furthermore, older Metrnl−/− mice develop inflammatory lesions, suggesting that Metrnl participates in the control of inflammatory responses. Taken together, these observations indicate that Metrnl encodes a novel immunoregulatory cytokine associated with inflammatory responses that we have designated Meteorin-β. |
| Databáze: | OpenAIRE |
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