Temporal single-cell regeneration studies: the greatest thing since sliced pancreas?
| Autor: | Mirza Muhammad Fahd Qadir, Ricardo L. Pastori, Juan Domínguez-Bendala |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Regeneration (biology) Cell Cell Differentiation 030209 endocrinology & metabolism Context (language use) Biology Article 03 medical and health sciences 0302 clinical medicine Endocrinology medicine.anatomical_structure Lineage tracing medicine Humans Regeneration Cell Lineage Progenitor cell Pancreas Neuroscience |
| Zdroj: | Trends Endocrinol Metab |
| ISSN: | 1043-2760 |
| Popis: | The application of single-cell analytic techniques to the study of stem/progenitor cell niches supports the emerging view that pancreatic cell lineages are in a state of flux between differentiation stages. For all their value, however, such analyses merely offer a snapshot of the cellular palette of the tissue at any given time point. Conclusions about potential developmental/regeneration paths are solely based on bioinformatics inferences. In this context, the advent of new techniques for the long-term culture and lineage tracing of human pancreatic slices (HPSs) offers a virtual window into the native organ and presents the field with a unique opportunity to serially resolve pancreatic regeneration dynamics at the single-cell level. |
| Databáze: | OpenAIRE |
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