Quantitative MRI evaluation of glaucomatous changes in the visual pathway
Autor: | Koji M. Nishiguchi, Mana Fukuda, Yasuko Tatewaki, Toru Nakazawa, Yasuyuki Taki, Izumi Matsudaira, Kazuko Omodaka, Noriko Himori, Takaki Murata |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Central Nervous System
Male Eye Diseases genetic structures Glaucoma lcsh:Medicine Pathology and Laboratory Medicine Nervous System Diagnostic Radiology 0302 clinical medicine Medicine and Health Sciences Brain Damage Prospective Studies Gray Matter lcsh:Science Visual Cortex Multidisciplinary medicine.diagnostic_test Radiology and Imaging Brain Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure Neurology Optic nerve Female Anatomy medicine.symptom Glaucoma Open-Angle Research Article Adult medicine.medical_specialty Imaging Techniques Central nervous system Neuroimaging Brain damage Research and Analysis Methods 03 medical and health sciences Signs and Symptoms Atrophy Ocular System Diagnostic Medicine Ophthalmology medicine Humans Aged Retina business.industry lcsh:R Biology and Life Sciences Optic Nerve Magnetic resonance imaging medicine.disease eye diseases Cross-Sectional Studies Visual cortex 030221 ophthalmology & optometry lcsh:Q business 030217 neurology & neurosurgery Neuroscience |
Zdroj: | PLoS ONE, Vol 13, Iss 7, p e0197027 (2018) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Background The aims of this study were to investigate glaucomatous morphological changes quantitatively in the visual cortex of the brain with voxel-based morphometry (VBM), a normalizing MRI technique, and to clarify the relationship between glaucomatous damage and regional changes in the visual cortex of patients with open-angle glaucoma (OAG). Methods Thirty-one patients with OAG (age: 55.9 ± 10.7, male: female = 9: 22) and 20 age-matched controls (age: 54.9 ± 9.8, male: female = 10: 10) were included in this study. The cross-sectional area (CSA) of the optic nerve was manually measured with T2-weighed MRI. Images of the visual cortex were acquired with T1-weighed 3D magnetization-prepared rapid acquisition with gradient echo (MPRAGE) sequencing, and the normalized regional visual cortex volume, i.e., gray matter density (GMD), in Brodmann areas (BA) 17, 18, and 19, was calculated with a normalizing technique based on statistic parametric mapping 8 (SPM8) analysis. We compared the regional GMD of the visual cortex in the control subjects and OAG patients. Spearman’s rank correlation analysis was used to determine the relationship between optic nerve CSA and GMD in BA 17, 18, and 19. Results We found that the normal and OAG patients differed significantly in optic nerve CSA (p < 0.001) and visual cortex GMD in BA 17 (p = 0.030), BA 18 (p = 0.003), and BA 19 (p = 0.005). In addition, we found a significant correlation between optic nerve CSA and visual cortex GMD in BA 19 (r = 0.33, p = 0.023), but not in BA 17 (r = 0.17, p = 0.237) or BA 18 (r = 0.24, p = 0.099). Conclusion Quantitative MRI parametric evaluation of GMD can detect glaucoma-associated anatomical atrophy of the visual cortex in BA 17, 18, and 19. Furthermore, GMD in BA 19 was significantly correlated to the damage level of the optic nerve, as well as the retina, in patients with OAG. This is the first demonstration of an association between the cortex of the brain responsible for higher-order visual function and glaucoma severity. Evaluation of the visual cortex with MRI is thus a very promising potential method for objective examination in OAG. |
Databáze: | OpenAIRE |
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