Insulin Secretion in Adrenergic Insufficiency in Man
| Autor: | Robert G. Brodows, F. Xavier Pi-Sunyer, Robert G. Campbell |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Adrenergic Biochemistry Endocrinology Internal medicine medicine Humans Insulin Sympathectomy Insulin secretion Pulse (signal processing) business.industry Basal insulin Biochemistry (medical) Adrenalectomy Adrenergic nervous system Middle Aged Receptors Adrenergic Glucose Basal (medicine) Intravenous glucose Female business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 38:1103-1108 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-38-6-1103 |
| Popis: | In order to evaluate the role of the adrenergic nervous system in the regulation of insulin secretion, 11 normal subjects, 5 adrenalectomized and 6 sympathectomized patients were given rapid intravenous glucose doses of 5 g and 20 g on 2 separate days. The acute insulin response was expressed as the mean 3′-5′ insulin increment (ΔIRI), the percent basal insulin, total incremental insulin area, and the ratio of ΔIRI to the mean 3′-5′ glucose increment. Basal glucose and insulin levels were not significantly different when normal subjects were compared to adrenalectomized and sympathectomized patients. In all three groups the mean 3′-5′ glucose increment to both the 5 g and 20 g glucose pulse was similar. The acute insulin response to both 5 g and 20 g glucose injections in adrenalectomized and sympathectomized patients was not statistically different than normal, regardless of the method of calculation. In addition, there was virtually no difference between any of the three groups in the magnitude... |
| Databáze: | OpenAIRE |
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