Babesia bovis: Dextran sulphate as an adjuvant for and precipitant of protective immunogens
| Autor: | I.G. Wright, B.V. Goodger, M.A. Commins, D.J. Waltisbuhl |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Erythrocytes
medicine.medical_treatment Cattle Diseases Parasitemia Biology Microbiology chemistry.chemical_compound Adjuvants Immunologic Immunity Babesiosis parasitic diseases medicine Animals Dextran Sulfate Vaccination Babesia bovis medicine.disease biology.organism_classification Virology Infectious Diseases Dextran chemistry Babesia biology.protein Cattle Parasitology Antibody Adjuvant |
| Zdroj: | International Journal for Parasitology. 22:465-469 |
| ISSN: | 0020-7519 |
| Popis: | Dextran sulphate, a chemical with some specificity for lipoproteins, was used to precipitate a fraction from a soluble extract of Babesia bovis-infected erythrocytes. The precipitate, in combination with dextran sulphate as an adjuvant, was used to vaccinate naive calves. The vaccinates and a group of control calves were challenged with virulent homologous B. bovis. The vaccinates showed delayed and decreased parasitaemias comparative to the controls. The antibody response to vaccination was primarily against the infected erythrocyte being of both IgG1 and IgG2 classes. We believe this is the first report of B. bovis antibody being detected in the IgG2 class. Lipase inhibition and chemical analysis suggested babesial lipid or lipoprotein was sufficiently immunogenic to produce serologically detectable antibody and presumably to elicit immunity. |
| Databáze: | OpenAIRE |
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