Winter birth and biological family history in adopted schizophrenics
| Autor: | Dennis K. Kinney, Lennart Jansson, Michelle Suozzo, Bjørn Jacobsen, Britta Faber, Sharon J. Tramer |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Proband
Psychosis Denmark Population Birth rate Developmental psychology Pregnancy Adoption Prevalence medicine Humans Family history Birth Rate education Biological Psychiatry Retrospective Studies education.field_of_study Confounding medicine.disease Psychiatry and Mental health Schizophrenia Chronic Disease Etiology Female Seasons Psychology Demography |
| Zdroj: | Schizophrenia Research. 44:95-103 |
| ISSN: | 0920-9964 |
| Popis: | To investigate relationships between birth season and biological family history in schizophrenia, this study used a sample of schizophrenics that had the advantages of (a) particularly thorough diagnostic assessments of schizophrenics' relatives, including information from direct interviews as well as chart reviews, and (b) schizophrenic probands who were adopted at early age, mitigating the usual confounding of genetic and postnatal environmental influences of the family. Adopted schizophrenics with no biological family history of schizophrenia-spectrum disorders were significantly more likely to be born in winter months than were either (a) their own biological relatives, including their sibs and half-sibs, (b) schizophrenics with a positive family history for schizophrenia-spectrum disorders, or (c) people in the general population. Family-history-positive schizophrenics and their schizophrenic relatives were, in turn, significantly less likely than their own non-schizophrenic biological relatives to be born in the winter; schizophrenics in these families tended to be born in the milder-weather seasons, particularly the spring and fall. Results suggest that environmental factors associated with winter birth may be etiologically important in schizophrenia, particularly for cases in which familial liability factors are weak. By contrast, a familial, probably genetic, liability factor may be especially important in schizophrenics born in mild weather. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect