Natural substance rutin versus standard drug atorvastatin in a treatment of metabolic syndrome-like condition

Autor: Karol Svik, Ružena Sotníková, Barbara Kaprinay, Lukáš Slovák, Dominika Michalikova, Vladimir Knezl, Boris Lipták, Zdenka Gasparova
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Rutin
OGTT
oral glucose tolerance test
Atorvastatin
Pharmaceutical Science
Morris water navigation task
Pharmacology
chemistry.chemical_compound
0302 clinical medicine
Blood serum
HTG
hypertriacylglycerolemic
HTG-HFFD-A
hypertriacylglycerolemic rat with high-fat-high-fructose diet with atorvastatin
Aorta
NOS
NO synthase
medicine.diagnostic_test
PXR
pregnane X receptor
eNOS
endothelial NO synthase
Glc
glucose
HFFD
high-fat-high-fructose diet
TG
triacylglycerols
Metabolic syndrome
IRS-1
insulin receptor substrate 1
ANOVA
one-way analysis of variance
cAMP
cyclic adenosine monophosphate
HMG-CoA
β-hydroxy β-methylglutaryl-CoA
MetS
metabolic syndrome
lipids (amino acids
peptides
and proteins)
HTG-HFFD
hypertriacylglycerolemic rat with high-fat-high-fructose diet
medicine.drug
O2¯
superoxide anion
GLUT-4
glucose transporter 4
SEM
standard error of the mean
Article
03 medical and health sciences
Spatial memory
ROS
reactive oxygen species
medicine.artery
HTG-HFFD-R
hypertriacylglycerolemic rat with high-fat-high-fructose diet with rutin
medicine
PKC
proteinkinase C
LDL-cholesterol
low density lipoprotein cholesterol
AD
Alzheimer disease
ACh
acetylcholine
business.industry
lcsh:RM1-950
nutritional and metabolic diseases
medicine.disease
MWM
Morris water maze
030104 developmental biology
lcsh:Therapeutics. Pharmacology
Dyslipidemia
chemistry
HDL-cholesterol
high density lipoprotein cholesterol
Lipid profile
business
030217 neurology & neurosurgery
Zdroj: Saudi Pharmaceutical Journal, Vol 27, Iss 8, Pp 1196-1202 (2019)
Saudi Pharmaceutical Journal : SPJ
ISSN: 1319-0164
Popis: Background: Metabolic syndrome is a cluster of metabolic risk factors. The clear causes of its development are not known yet and there is no comprehensive treatment of this disease. There is a trend to use natural substances in the treatment of various diseases, but their effects need to be well explored. We decided to test effect of rutin compared to the effect of the standard drug atorvastatin. Methods: As a model of metabolic syndrome we used males of hypertriacylglycerolemic rats in combination with high-fat-high-fructose diet. Rutin (100 mg/kg) and atorvastatin (50 mg/kg) were administered orally daily for 5 weeks. Results: We determined biochemical parameters from blood: HDL-cholesterol, LDL-cholesterol, total cholesterol, triacylglycerols. Relaxation and contraction response of aorta was measured to determine vessel dysfunctions and possible predisposition to cardiovascular disease. The negative influence on cognitive functions could be associated with the development of metabolic cognitive syndrome. Therefore we aimed to monitor spatial memory by Morris water maze test. Both rutin and atorvastatin had a tendency to decrease levels of serum triacylglycerols, but only atorvastatin significantly reduced levels od LDL-cholesterol and increased HDL-cholesterol levels. Both compounds significantly reduced the phenylephrine-induced contractile response of the aorta and improved the relaxation response. Further, treated animals learned better compared to untreated rats in the Morris water maze. Conclusion: Based on our results we can assume that atorvastatin and rutin had positive effect on spatial memory and vessel reactivity. Atorvastatin optimized lipid profile of blood serum. Keywords: Metabolic syndrome, Rutin, Atorvastatin, Dyslipidemia, Aorta, Spatial memory
Databáze: OpenAIRE
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