Natural substance rutin versus standard drug atorvastatin in a treatment of metabolic syndrome-like condition
Autor: | Karol Svik, Ružena Sotníková, Barbara Kaprinay, Lukáš Slovák, Dominika Michalikova, Vladimir Knezl, Boris Lipták, Zdenka Gasparova |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Rutin OGTT oral glucose tolerance test Atorvastatin Pharmaceutical Science Morris water navigation task Pharmacology chemistry.chemical_compound 0302 clinical medicine Blood serum HTG hypertriacylglycerolemic HTG-HFFD-A hypertriacylglycerolemic rat with high-fat-high-fructose diet with atorvastatin Aorta NOS NO synthase medicine.diagnostic_test PXR pregnane X receptor eNOS endothelial NO synthase Glc glucose HFFD high-fat-high-fructose diet TG triacylglycerols Metabolic syndrome IRS-1 insulin receptor substrate 1 ANOVA one-way analysis of variance cAMP cyclic adenosine monophosphate HMG-CoA β-hydroxy β-methylglutaryl-CoA MetS metabolic syndrome lipids (amino acids peptides and proteins) HTG-HFFD hypertriacylglycerolemic rat with high-fat-high-fructose diet medicine.drug O2¯ superoxide anion GLUT-4 glucose transporter 4 SEM standard error of the mean Article 03 medical and health sciences Spatial memory ROS reactive oxygen species medicine.artery HTG-HFFD-R hypertriacylglycerolemic rat with high-fat-high-fructose diet with rutin medicine PKC proteinkinase C LDL-cholesterol low density lipoprotein cholesterol AD Alzheimer disease ACh acetylcholine business.industry lcsh:RM1-950 nutritional and metabolic diseases medicine.disease MWM Morris water maze 030104 developmental biology lcsh:Therapeutics. Pharmacology Dyslipidemia chemistry HDL-cholesterol high density lipoprotein cholesterol Lipid profile business 030217 neurology & neurosurgery |
Zdroj: | Saudi Pharmaceutical Journal, Vol 27, Iss 8, Pp 1196-1202 (2019) Saudi Pharmaceutical Journal : SPJ |
ISSN: | 1319-0164 |
Popis: | Background: Metabolic syndrome is a cluster of metabolic risk factors. The clear causes of its development are not known yet and there is no comprehensive treatment of this disease. There is a trend to use natural substances in the treatment of various diseases, but their effects need to be well explored. We decided to test effect of rutin compared to the effect of the standard drug atorvastatin. Methods: As a model of metabolic syndrome we used males of hypertriacylglycerolemic rats in combination with high-fat-high-fructose diet. Rutin (100 mg/kg) and atorvastatin (50 mg/kg) were administered orally daily for 5 weeks. Results: We determined biochemical parameters from blood: HDL-cholesterol, LDL-cholesterol, total cholesterol, triacylglycerols. Relaxation and contraction response of aorta was measured to determine vessel dysfunctions and possible predisposition to cardiovascular disease. The negative influence on cognitive functions could be associated with the development of metabolic cognitive syndrome. Therefore we aimed to monitor spatial memory by Morris water maze test. Both rutin and atorvastatin had a tendency to decrease levels of serum triacylglycerols, but only atorvastatin significantly reduced levels od LDL-cholesterol and increased HDL-cholesterol levels. Both compounds significantly reduced the phenylephrine-induced contractile response of the aorta and improved the relaxation response. Further, treated animals learned better compared to untreated rats in the Morris water maze. Conclusion: Based on our results we can assume that atorvastatin and rutin had positive effect on spatial memory and vessel reactivity. Atorvastatin optimized lipid profile of blood serum. Keywords: Metabolic syndrome, Rutin, Atorvastatin, Dyslipidemia, Aorta, Spatial memory |
Databáze: | OpenAIRE |
Externí odkaz: |