Seroprevalences of Antibodies to 11 Human Papillomavirus (HPV) Types Mark Cumulative HPV Exposure
| Autor: | Hanna Artemchuk, Joakim Dillner, Helena Faust, Anja Oštrbenk, Mario Poljak, Tina Triglav |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Genotype Slovenia Antibodies Viral Sensitivity and Specificity Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Seroepidemiologic Studies Humans Immunology and Allergy Medicine Sex organ Longitudinal Studies 030212 general & internal medicine Human papillomavirus Seroconversion Papillomaviridae Early Detection of Cancer Hpv types biology business.industry Papillomavirus Infections virus diseases Odds ratio Middle Aged Virology female genital diseases and pregnancy complications Confidence interval 030104 developmental biology Infectious Diseases Concomitant DNA Viral biology.protein Female Antibody business |
| Zdroj: | The Journal of Infectious Diseases. 218:398-405 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Background The antibody responses against human papillomavirus type 16 (HPV-16) and HPV-18 are well known, but many genital HPV types are oncogenic. We assessed the correlation between detection of type-specific HPV DNA and antibodies for 11 HPV types. Methods A total of 2024 women attending the organized national cervical cancer screening program in Slovenia were tested for cervical high-risk HPV DNA (HPV-16, -18, -31, -33, -35, -39, -45, -52, -56, -58, -59, and -68) and serum anti-HPV antibodies. Of these, 1848 women were tested with the same methods 3 years earlier. Results Type-specific antibodies against 10 of 11 HPV types (HPV-16, -18, -31, -33, -35, -39, -45, -52, -56, and -58) were associated with concomitant presence of type-specific DNA (median odds ratio [OR], 7.5; 95% confidence interval [CI], 2.2-26.1). When the concomitant presence of type-specific HPV DNA at the 3-year visit was combined with the presence of the same HPV DNA type 3 years earlier, the statistical precision was greatly improved, and antibodies against all 11 types (HPV-16, -18, -31, -33, -35, -39, -45, -52, -56, -58, and -59) were associated with the presence of DNA of the same HPV type (median OR, 7.4; 95% CI, 4.2-12.8). Sensitivity had a slight tendency to increase (from 47% to 52%) when DNA positivity at the earlier time point was included, whereas specificity was the same (88%). Seroconversion was associated with previous HPV DNA positivity. Seropositivity mostly remained stable during the observation period. Conclusions For 11 HPV types, type-specific seropositivity was associated with the presence of DNA of the same HPV type (either concomitantly or previously). Antibodies to these HPV types mark cumulative HPV exposure. |
| Databáze: | OpenAIRE |
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