The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts
| Autor: | A Lazaris-Karatzas, Nahum Sonenberg |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
RNA Caps
Eukaryotic Initiation Factor-4E Blotting Western Genes myc RNA-binding protein macromolecular substances Biology Transfection environment and public health Peptide Initiation Factors medicine Animals Initiation factor heterocyclic compounds Fibroblast Molecular Biology Messenger RNA Binding protein Adenovirus Early Proteins RNA-Binding Proteins food and beverages Oncogene Proteins Viral Oncogenes Cell Biology Fibroblasts Molecular biology Rats Inbred F344 Rats Cell Transformation Neoplastic medicine.anatomical_structure RNA Cap-Binding Proteins health occupations Signal transduction Research Article |
| Zdroj: | Molecular and Cellular Biology. 12:1234-1238 |
| ISSN: | 1098-5549 0270-7306 |
| DOI: | 10.1128/mcb.12.3.1234 |
| Popis: | We present evidence that eIF-4E, the mRNA 5' cap-binding protein, cooperates with two immortalizing oncogenes, v-myc and E1A, to cause transformation of rat embryo fibroblasts. eIF-4E alone can transform rat embryo fibroblasts when selection is applied. The pattern of transformation by eIF-4E is similar to that of p21 Ras, raising the possibility that eIF-4E shares a common signal transduction pathway with p21 Ras. |
| Databáze: | OpenAIRE |
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