MicroRNAs in the Pathogenesis of Nonalcoholic Fatty Liver Disease
| Autor: | Lin Wang, Guorui Dou, Zhi-Qiang Fang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cirrhosis
Disease Bioinformatics digestive system Applied Microbiology and Biotechnology Pathogenesis 03 medical and health sciences Insulin resistance Non-alcoholic Fatty Liver Disease Nonalcoholic fatty liver disease Medicine Humans Molecular Biology Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences business.industry Fatty liver nutritional and metabolic diseases Type 2 Diabetes Mellitus Cell Biology medicine.disease Lipid Metabolism Hepatic stellate cell activation digestive system diseases MicroRNAs Oxidative Stress Liver business Developmental Biology |
| Zdroj: | International journal of biological sciences. 17(7) |
| ISSN: | 1449-2288 |
| Popis: | Nonalcoholic fatty liver disease (NAFLD), or, more accurately, metabolic associated fatty liver disease, accounts for a large proportion of chronic liver disorders worldwide and is closely associated with other conditions such as cardiovascular disease, obesity, and type 2 diabetes mellitus. NAFLD ranges from simple steatosis to nonalcoholic steatohepatitis (NASH) and can progress to cirrhosis and, eventually, also hepatocellular carcinoma. The morbidity and mortality associated with NAFLD are increasing rapidly year on year. Consequently, there is an urgent need to understand the etiology and pathogenesis of NAFLD and identify effective therapeutic targets. MicroRNAs (miRNAs), important epigenetic factors, have recently been proposed to participate in NAFLD pathogenesis. Here, we review the roles of miRNAs in lipid metabolism, inflammation, apoptosis, fibrosis, hepatic stellate cell activation, insulin resistance, and oxidative stress, key factors that contribute to the occurrence and progression of NAFLD. Additionally, we summarize the role of miRNA-enriched extracellular vesicles in NAFLD. These miRNAs may comprise suitable therapeutic targets for the treatment of this condition. |
| Databáze: | OpenAIRE |
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