A low-carbohydrate protein-rich bedtime snack to control fasting and nocturnal glucose in type 2 diabetes: A randomized trial

Autor: Julianne Barry, Monique E. Francois, Courtney R. Chang, Erica Abbie, Jonathan P. Little
Rok vydání: 2020
Předmět:
Blood Glucose
Male
0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
030209 endocrinology & metabolism
Glycemic Control
Type 2 diabetes
Critical Care and Intensive Care Medicine
Bedtime
law.invention
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Randomized controlled trial
law
Internal medicine
Humans
Medicine
Aged
Morning
Glycated Hemoglobin
2. Zero hunger
Cross-Over Studies
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Blood Glucose Self-Monitoring
Insulin
digestive
oral
and skin physiology
Quantitative insulin sensitivity check index
food and beverages
Fasting
Middle Aged
medicine.disease
Crossover study
Circadian Rhythm
3. Good health
Endocrinology
Diabetes Mellitus
Type 2
Hyperglycemia
Female
Insulin Resistance
Snacks
business
Diet
High-Protein Low-Carbohydrate
Zdroj: Clinical Nutrition. 39:3601-3606
ISSN: 0261-5614
0320-7269
DOI: 10.1016/j.clnu.2020.03.008
Popis: Summary In type 2 diabetes, liver insulin resistance and excess hepatic glucose production results in elevated fasting glucose. A bedtime snack has been recommended to improve fasting glucose, yet there is little evidence supporting this recommendation. Moreover, the optimal composition of a bedtime snack is unknown. Purpose To determine whether a low-carbohydrate protein-rich bedtime snack (Egg) could reduce fasting plasma glucose levels in people with type 2 diabetes when compared to a high-carbohydrate protein-rich bedtime snack (Yogurt) or a No Bedtime Snack condition. Secondary outcomes included glucose control assessed by continuous glucose monitoring (CGM) and fasting insulin sensitivity markers. Methods Using a randomized crossover design, participants with type 2 diabetes (N = 15) completed three separate isocaloric conditions: i) Egg, ii) Yogurt, and iii) No Bedtime Snack, each lasting three days. CGM was collected throughout and duplicate fasting blood samples were obtained on the morning of day 4 in each condition. Results Fasting plasma glucose (P = 0.04, d = 0.68), insulin (P = 0.04, d = 0.45), and nocturnal glucose (P = 0.02, d = 0.94) were significantly lower, and quantitative insulin sensitivity check index (QUICKI; P = 0.003) was improved, in the Egg compared to the Yogurt bedtime snack. There were no significant differences between either bedtime snack and No Bedtime Snack. Conclusion In the short-term, a low-carbohydrate bedtime snack (Egg) lowered fasting glucose and improved markers of insulin sensitivity when compared to a high-carbohydrate protein-matched bedtime snack (Yogurt). However, consuming a low- or high-carbohydrate bedtime snack did not appear to lower fasting glucose compared to consuming an isocaloric diet with no bedtime snack. Clinical trial registry clinicaltrials.gov ( NCT03207269 ).
Databáze: OpenAIRE
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