Acute high-dose sodium selenite administration improves intestinal microcirculation without affecting cytokine release in experimental endotoxemia
| Autor: | Michael F. Murphy, Michael Wendt, Matthias Gründling, Dragan Pavlovic, Konrad Meissner, Taras I. Usichenko, Sara Whynot, Orlando Hung, Daniela Saeger, Sandra Rickert, Christian Lehmann |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Sodium medicine.medical_treatment chemistry.chemical_element Pharmacology Biochemistry Microcirculation Inorganic Chemistry Sodium Selenite Intestinal microcirculation Cell Adhesion Leukocytes medicine Animals Intestinal Mucosa Capillary perfusion Interleukin-6 Tumor Necrosis Factor-alpha Functional capillary density Endotoxemia Interleukin-10 Rats Intestines Cytokine chemistry Rats Inbred Lew Immunology Cytokines Molecular Medicine Selenium |
| Zdroj: | Journal of Trace Elements in Medicine and Biology. 23:138-143 |
| ISSN: | 0946-672X |
| Popis: | We evaluated the effects of acute high-dose sodium selenite (SEL) administration on the intestinal microcirculation and the release of the cytokines TNF-alpha, IL-1beta, IL-6 and IL-10 in experimental endotoxemia (induced by lipopolysaccharide-LPS). Three groups of animals (n=30) were studied: control group, endotoxemic group (15 mg kg(-1) i.v. LPS from E. coli) and SEL-treated LPS group (100 microg kg(-1) SEL i.v.). SEL treatment resulted in a significant reduced number of firmly adhering leukocytes in intestinal submucosal venules and reduced significantly the impairment of the intestinal functional capillary density. Despite of the improvement of microcirculatory parameters, we did not detect any changes in the pattern of cytokine release. In conclusion, administration of high-dose sodium SEL attenuates leukocyte adhesion and improves capillary perfusion within the intestinal microcirculation without affecting release of the cytokines TNF-alpha, IL-1beta, IL-6 and IL-10 in experimental endotoxemia. |
| Databáze: | OpenAIRE |
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