Inhibition of oestradiol-induced prolactin release in a dual-cannulated ovariectomized rat model by carmoxirole, a peripherally restricted dopamine agonist
| Autor: | Jennifer L. Werkheiser, Maneesha Altekar, Lewis B. Kinter, Jane Stewart, Håkan H. A. S. Andersson, David Brott, Pam Campbell, Patricia Bentley, Russell D. J. Huby |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Agonist
endocrine system medicine.medical_specialty Indoles medicine.drug_class Pyridines Ovariectomy Dopamine transport Pharmacology Biology Toxicology Dopamine agonist Piperazines Prolactin cell Dopamine Internal medicine medicine Animals Rats Wistar Bromocriptine Estradiol Estrogen Antagonists General Medicine Prolactin Stimulation Chemical Rats Endocrinology Dopamine receptor Dopamine Agonists Female hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Basicclinical pharmacologytoxicology. 111(6) |
| ISSN: | 1742-7843 |
| Popis: | Centrally acting dopamine agonists (e.g. bromocriptine) and dopamine transport inhibitors (e.g. GBR12909) are known to inhibit oestradiol-induced prolactin release. The capacity of peripherally restricted compounds to do likewise, however, is unknown. Here, the effects of the peripherally restricted dopamine receptor agonist carmoxirole on oestradiol-induced prolactin release were investigated. Dual-cannulated ovariectomized rats were used, so that a robust, reproducible response to exogenous oestrogen could be induced and sequential blood samples were taken with minimal stress. Carmoxirole (15 mg/kg) inhibited oestradiol-induced prolactin release, similar to bromocriptine and GBR12909. However, carmoxirole also induced a rapid, transient, oestradiol-independent release of prolactin. These data show that peripherally restricted dopamine receptor agonists are sufficient to inhibit oestradiol-induced prolactin release. Like centrally acting compounds, they may therefore be expected to affect the incidence of prolactin-dependent tumours in rat carcinogenesis studies without inducing central-mediated side effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|