Surgical decision-making in the management of childhood tumors of the CNS disseminated at presentation
| Autor: | Richard D. Hayward, Kim Phipps, Matthew A. Kirkman, Kristian Aquilina |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Ependymoma Pediatrics medicine.medical_specialty Adolescent Decision Making Population Ventriculoperitoneal Shunt Central Nervous System Neoplasms 03 medical and health sciences 0302 clinical medicine Image Processing Computer-Assisted medicine Humans Longitudinal Studies Child education Proportional Hazards Models Retrospective Studies Medulloblastoma education.field_of_study Pilocytic astrocytoma business.industry Infant Newborn Endoscopic third ventriculostomy Disease Management Infant Retrospective cohort study General Medicine medicine.disease Magnetic Resonance Imaging Child Preschool 030220 oncology & carcinogenesis Primitive neuroectodermal tumor Neuroendoscopy Atypical teratoid rhabdoid tumor Female business 030217 neurology & neurosurgery Hydrocephalus |
| Zdroj: | Journal of Neurosurgery: Pediatrics. 21:563-573 |
| ISSN: | 1933-0715 1933-0707 |
| Popis: | OBJECTIVEIt is relatively unusual for pediatric CNS tumors to be disseminated at presentation, and the literature on the clinical features, management, and outcomes of this specific group is scarce. Surgical management in this population is often challenging, particularly in the presence of hydrocephalus. The authors present their recent experience of treating pediatric CNS tumors that were disseminated at presentation, and they compare these lesions with focal tumors.METHODSThe authors performed a retrospective review of prospectively collected data on children presenting to a tertiary center between 2003 and 2016 inclusive.RESULTSOf 361 children with CNS tumors, the authors identified 53 patients with disease dissemination at presentation (male/female ratio 34:19, median age 3.8 years, age range 7 days to 15.6 years) and 308 without dissemination at presentation (male/female ratio 161:147, median age 5.8 years, age range 1 day to 16.9 years). Five tumor groups were studied: medulloblastoma (disseminated n = 29, focal n = 74), other primitive neuroectodermal tumor (n = 8, n = 17), atypical teratoid rhabdoid tumor (n = 8, n = 22), pilocytic astrocytoma (n = 6, n = 138), and ependymoma (n = 2, n = 57). The median follow-up duration in survivors was not significantly different between those with disease dissemination at presentation (64.0 months, range 5.2–152.0 months) and those without it (74.5 months, range 4.7–170.1 months) (p > 0.05). When combining data from all 5 tumor groups, dissemination status at presentation was significantly associated with a higher risk of requiring CSF diversion, a higher surgical complication rate, and a reduced likelihood of achieving gross-total resection of the targeted lesion (all variables p < 0.05). Differences between the 5 tumor groups were evident. No factors that predicted the need for permanent CSF diversion following temporary external ventricular drainage were identified on multivariate analysis, and there was no clear superiority of either ventriculoperitoneal shunt surgery or endoscopic third ventriculostomy as a permanent CSF diversion procedure.CONCLUSIONSTumor type and dissemination status at initial presentation significantly affect outcomes across a range of measures. The management of hydrocephalus in patients with CNS tumors is challenging, and further prospective studies are required to identify the optimal CSF diversion strategy in this population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|