Elevated Concentrations of Interleukins and Leukotriene in Response toMycobacterium TuberculosisInfection
| Autor: | Mahmoud A. Mansour, O Mansour, O El-Ahmady, H Zoeir |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
030213 general clinical medicine Tuberculosis Adolescent Leukotriene B4 medicine.medical_treatment Clinical Biochemistry 030209 endocrinology & metabolism Biology Mycobacterium tuberculosis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood plasma medicine Humans Chromatography High Pressure Liquid Leukotriene Lung Interleukin-6 Respiratory disease Granulocyte-Macrophage Colony-Stimulating Factor General Medicine medicine.disease biology.organism_classification Leukotriene C4 medicine.anatomical_structure Cytokine chemistry Immunology |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 34:160-164 |
| ISSN: | 1758-1001 0004-5632 |
| Popis: | There is significant research in the role of interleukins in lung disease, as the cytokines are important mediators in the host response to mycobacterium tuberculosis infection. Plasma from patients with pulmonary tuberculosis (TB) and healthy controls were investigated for their content of granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-6 (IL-6) and leukotriene B4(LTB4). LTB4and IL-6 were measured by enzyme immunoassay after lipid extraction in the case of LTB4while GM-CSF was measured by enzyme amplified sensitive immunoassay. Significantly elevated concentrations of IL-6 were found in far-advanced lesions of pulmonary tuberculosis patients, P < 0·05. However, nonsignificant increases of IL-6 were obtained in moderate lesions and minimal lesions compared to normal healthy subjects. Marked elevations of LTB4were found in TB patients, the highest values being shown in patients with far-advanced lesions followed by moderately advanced and minimal lesions in relation to the mean value for normal healthy controls, P < 0·001 for all groups. 93% of the tuberculosis patients showed a higher level of LTB4above the upper limit of the control group. In contrast there was no significant increase of GM-CSF in any of the TB subgroups. These results suggest that LTB4and the interleukins may play a role in the pathogenesis of mycobacterium tuberculosis infection. |
| Databáze: | OpenAIRE |
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