Glyoxylamide-based self-assembly hydrogels for sustained ciprofloxacin delivery
Autor: | Shashidhar Nizalapur, Lars M. Ittner, Pall Thordarson, David StC. Black, Anne M. Rich, Christopher E. Marjo, Naresh Kumar, Adam D. Martin, Kitty K. K. Ho, Vina R. Aldilla |
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Rok vydání: | 2018 |
Předmět: |
chemistry.chemical_classification
Low toxicity technology industry and agriculture Biomedical Engineering Peptide Fiber morphology 02 engineering and technology General Chemistry General Medicine 010402 general chemistry 021001 nanoscience & nanotechnology complex mixtures 01 natural sciences 0104 chemical sciences Ciprofloxacin chemistry Chemical engineering Mechanical strength Self-healing hydrogels medicine General Materials Science Self-assembly 0210 nano-technology Protein secondary structure medicine.drug |
Zdroj: | Journal of Materials Chemistry B. 6:6089-6098 |
ISSN: | 2050-7518 2050-750X |
Popis: | In this study, we report the synthesis of glyoxylamide peptide-mimics as self-assembled gels with well-defined molecular structures for topical delivery of ciprofloxacin (CIP). The glyoxylamide peptide mimics successfully formed hydrogels with critical gel concentrations of 0.02-0.08% (w/v). The mechanical strength, secondary structure, and fiber morphology of these hydrogels can be modulated by varying the N-substituent of the ring-opened isatins. The synthesised hydrogel exhibited a high loading capacity of CIP (40% (w/w)) and a sustained release profile. The CIP-loaded hydrogels were able to release CIP for more than 15 days and the released solution was shown to retain activity against Gram-positive and Gram-negative bacteria. In addition, the hydrogels formed showed low toxicity against Cos7 cells. |
Databáze: | OpenAIRE |
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