Genotoxicity of structurally related copper and zinc containing Schiff base complexes

Autor:	Arwa Dodeen, Soleiman Hisaindee, Karem H. Alzoubi, Leena Al-Kaabi, Omar F. Khabour, Doaa Al-Fyad, Fatima T. Esmadi, Na’il Saleh
Rok vydání:	2013
Předmět:	Stereochemistry Health Toxicology and Mutagenesis chemistry.chemical_element Sister chromatid exchange Zinc Naphthalenes Toxicology medicine.disease_cause chemistry.chemical_compound medicine Animals Lymphocytes Schiff Bases Naphthalene Pharmacology Chromosome Aberrations Chemical Health and Safety Schiff base Dose-Response Relationship Drug Molecular Structure Mutagenicity Tests Public Health Environmental and Occupational Health Deoxyguanosine General Medicine Copper Rats chemistry 8-Hydroxy-2'-Deoxyguanosine Spectrophotometry Ultraviolet Sister Chromatid Exchange Genotoxicity Nuclear chemistry Conjugate DNA Damage
Zdroj:	Drug and chemical toxicology. 36(4)
ISSN:	1525-6014
Popis:	The utilization of Schiff bases in the industrial and pharmaceutical fields has led to an increase in their syntheses and evaluation of their biological activities. In this study, we described the synthesis and genotoxicity of two Schiff bases that share common platform in their construction, namely, naphthalene, and are complexed to either Cu(II) or Zn(II). The genotoxicity of these complexes was evaluated in cultured lymphocytes using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs), and in rats using the urine 8-OH-2-deoxyguanosine (8-OH-dG) assay. The results showed that the examined complexes are genotoxic, but with different degrees. The order of genotoxicity of the complexes at 10 µg/mL was: Cu(L3)(NCS)(H2O) Zn(L3)(NCS)(H2O)Cu(L2)(NCS) Zn(L2)(NCS), where L2 and L3 are the conjugate bases of N-(8-quinolyl)napthaldimine and N-(anilinyl)napthaldimine, respectively. However, at the 1-µg/mL concentration, only the Cu(L3)(NCS)(H2O) complex induced significant CAs, whereas at the 0.1-µg/mL concentration, only Cu(L3)(NCS)(H2O) and Zn(L2)(NCS) complexes induced significant SCEs, compared to controls. In the urine 8-OH-dG assay, all complexes at 10 mg/100 g body weight (b.w.) were found to cause DNA damage with the following order: Cu(L3)(NCS)(H2O)Zn(L2)(NCS)Zn(L3)(NCS)(H2O)Cu(L2)(NCS), whereas no significant DNA damage was observed in animals exposed to 1 and 0.1 mg/100 g b.w. (p0.05). In conclusion, the two examined Schiff base complexes are found to induce DNA damage, but with different degrees.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfc891d538d30e0b0b4f91d1de6c21f https://pubmed.ncbi.nlm.nih.gov/23528207 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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