GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation
| Autor: | Stephanie K. Dougan, Michael Dougan, Glenn Dranoff |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Immunology Inflammation Disease Biology Autoimmune Diseases Mice Structure-Activity Relationship 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Animals Humans Immunology and Allergy Interleukin 5 Mice Knockout Autoimmune disease Wound Healing Vaccination Granulocyte-Macrophage Colony-Stimulating Factor Receptors Interleukin-5 medicine.disease Receptors Interleukin-3 Recombinant Proteins Hematopoiesis Haematopoiesis 030104 developmental biology Infectious Diseases Cytokine Granulocyte macrophage colony-stimulating factor Receptors Granulocyte-Macrophage Colony-Stimulating Factor Multigene Family 030220 oncology & carcinogenesis Interleukin-3 Interleukin-5 medicine.symptom Signal transduction Signal Transduction medicine.drug |
| Zdroj: | Immunity. 50:796-811 |
| ISSN: | 1074-7613 |
| Popis: | The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmune disease, and others show promising early clinical activity. These approaches are based on our understanding of the inflammatory roles of these cytokines; however, GM-CSF also participates in the resolution of inflammation, and IL-3 and IL-5 may also have such properties. Here, we review the functions of the β common cytokines in health and disease. We discuss preclinical and clinical data, highlighting the potential inherent in targeting these cytokine pathways, the limitations, and the important gaps in understanding of the basic biology of this cytokine family. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|