Failure of Growth Hormone (GH) to Feed Back at the Level of the Pituitary to Alter the Response of the Somatotrophs to GH-Releasing Factor*
| Autor: | Benoit Lussier, B. C. Moor, J. Kraicer, J. S. Cowan |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Time Factors Somatotropic cell Central nervous system Peptide hormone Biology Growth Hormone-Releasing Hormone Growth hormone Endocrinology Pituitary Gland Anterior Reference Values Internal medicine medicine Animals Feed back Pulse (signal processing) Growth hormone–releasing hormone Rats Perfusion medicine.anatomical_structure Somatostatin Growth Hormone hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrinology. 122:1511-1514 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-122-4-1511 |
| Popis: | GH feeds back at the level of the central nervous system to alter the release of somatostatin and GRF, resulting in altered GH release. The purpose of this study was to see whether the concentration of GH, impinging directly on the somatotrophs of the adenohypophysis, would alter the responsiveness of the somatotrophs to GRF. Using a perifusion system and dispersed pituitary cells, we found that the GH response to a pulse of GRF is unaltered over a wide range of GH concentrations. We conclude that GH does not feed back at the level of the adenohypophysis to alter the responsiveness of the somatotrophs to GRF. |
| Databáze: | OpenAIRE |
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