Impact of Skeletal Muscle Mass on Long-Term Adverse Cardiovascular Outcomes in Patients With Chronic Kidney Disease
| Autor: | Hideki Ishii, Kenshi Hirayama, Susumu Suzuki, Yohei Shibata, Ayako Kunimura, Ryota Morimoto, Kazuhiro Kawashima, Yosuke Tatami, Takuya Sumi, Toshijiro Aoki, Yusaku Shimbo, Kazuhiro Harada, Yosuke Negishi, Toyoaki Murohara, Toshiki Kawamiya, Yoshinari Yasuda, Dai Yamamoto |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Sarcopenia 030232 urology & nephrology Myocardial Infarction Renal function 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Japan Internal medicine medicine Myocardial Revascularization Humans Mass index Renal Insufficiency Chronic Aged Proportional Hazards Models Psoas Muscles Aged 80 and over Heart Failure business.industry Smoking Skeletal muscle Middle Aged medicine.disease medicine.anatomical_structure C-Reactive Protein Cardiology Median body Female Cardiology and Cardiovascular Medicine business Tomography X-Ray Computed Body mass index Mace Kidney disease Glomerular Filtration Rate |
| Zdroj: | The American journal of cardiology. 119(8) |
| ISSN: | 1879-1913 |
| Popis: | Sarcopenia, defined as skeletal muscle loss and dysfunction, is attracting considerable attention as a novel risk factor for cardiovascular events. Although the loss of skeletal muscle is common in chronic kidney disease (CKD) patients, the relation between sarcopenia and cardiovascular events in CKD patients is not well defined. Therefore, we aimed to investigate the relation between skeletal muscle mass and major adverse cardiovascular events (MACE) in CKD patients. We enrolled 266 asymptomatic CKD patients (median estimated glomerular filtration rate: 36.7 ml/min/1.73 m 2 ). To evaluate skeletal muscle mass, we used the psoas muscle mass index (PMI) calculated from noncontrast computed tomography. The patients were divided into 2 groups according to the cut-off value of PMI for MACE. There were significant differences in age and body mass index between the low and high PMI groups (median age: 73.5 vs 69.0 years, p = 0.002; median body mass index: 22.6 vs 24.2 kg/m 2 , p |
| Databáze: | OpenAIRE |
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