Low doses of pentagastrin stimulate gastric lipase secretion in man
| Autor: | Berit Sternby, H. Worning, Morten Wojdemann, Ole Olsen, P. Nørregaard |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Triacylglycerol lipase Enzyme-Linked Immunosorbent Assay chemistry.chemical_compound Internal medicine medicine Humans Gastric lipase Secretion Lipase Gastric Juice biology Triglyceride Dose-Response Relationship Drug Chemistry Stomach digestive oral and skin physiology Gastroenterology Hydrogen-Ion Concentration Pentagastrin Endocrinology medicine.anatomical_structure Injections Intravenous biology.protein Female Digestion medicine.drug |
| Zdroj: | Scandinavian journal of gastroenterology. 30(7) |
| ISSN: | 0036-5521 |
| Popis: | Background: Gastric lipase is an important enzyme for dietary triglyceride digestion in normal subjects. Its regulation is unknown, as is the relation between the quantity and activity of the enzyme.Methods: In a dose-response study we investigated the effect of low doses of pentagastrin (less than 1000 ng/kg/h) on the output of gastric lipase measured by a kinetic assay and an enzyme-linked immunosorbent assay (ELISA).Results: In five healthy volunteers stepwise intravenous pentagastrin infusions of 0, 50, 100,500, and 1000 ng/kg/h resulted in a stepwise increase in the lipase output, as measured with ELISA. However, the lipolytic activity, measured with a kinetic assay, decreased as the pH of the gastric contents decreased.Conclusion: We conclude that secretion of the gastric lipase is stimulated by pentagastrin, but the simultaneous secretion of acid counteracts the lipolytic activity of the enzyme when food is not present. |
| Databáze: | OpenAIRE |
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