Desferrioxamine–cadmium as a ‘Trojan horse’ for the delivery of Cd to bacteria and fungi
| Autor: | Delia Manuela Luna Pinto, Vera R. L. Constantino, Breno Pannia Espósito, Ricardo Alexandre Alves de Couto, Ana Luiza Costa Mattos, Telma Mary Kaneko |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Siderophore
Metal ions in aqueous solution chemistry.chemical_element Microbial Sensitivity Tests Deferoxamine Cadmium chloride Spectrum Analysis Raman medicine.disease_cause Biochemistry Mass Spectrometry Microbiology Coordination complex Inorganic Chemistry chemistry.chemical_compound X-Ray Diffraction Spectroscopy Fourier Transform Infrared medicine Escherichia coli chemistry.chemical_classification Cadmium Bacteria Calorimetry Differential Scanning biology Fungi biology.organism_classification chemistry Thermogravimetry Molecular Medicine PSEUDOMONAS Powders Derivative (chemistry) Nuclear chemistry |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0946-672X |
| DOI: | 10.1016/j.jtemb.2012.09.001 |
| Popis: | Summary Molecules naturally designed for the acquisition of essential metals can be used as a shuttle to deliver toxic metal ions to target organisms. In this study, we describe for the first time the synthesis of a derivative of cadmium and desferrioxamine B, a bacterial siderophore. The new compound was characterized by elemental analysis, vibrational (infrared and Raman) spectroscopy, mass coupled thermal analyses and X-ray diffraction methods. Studies on the in vitro toxicity toward a fungus and two bacterial strains indicated that the coordination compound is more active against microrganisms than cadmium chloride on a Cd-concentration basis, indicating that desferrioxamine can work as a “Trojan horse” in the delivery of a toxic metal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect