Lipid accumulation product (LAP) as a criterion for the identification of the healthy obesity phenotype in postmenopausal women
| Autor: | Andrzej Milewicz, Leszek Szmigiero, Diana Jędrzejuk, Felicja Lwow |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Aging
medicine.medical_specialty Blood lipids 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Biochemistry 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Internal medicine Metabolically healthy obesity Genetics medicine Body Fat Distribution Humans Molecular Biology Obesity Metabolically Benign Anthropometry business.industry Cell Biology Middle Aged medicine.disease Obesity Postmenopause Phenotype Blood pressure ROC Curve Female Poland Metabolic syndrome Lipid Accumulation Product business Body mass index |
| Zdroj: | Experimental Gerontology. 82:81-87 |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2016.06.007 |
| Popis: | Obesity and its complications constitute a major health problem in postmenopausal women. The identification of the obesity phenotype, especially that of metabolically healthy obese (MHO) patients, is a necessary part of obesity treatment protocols. There are several methods to define MHO, but unfortunately, all of them are arbitrary and inconsistent. The aim of this work was to determine whether lipid accumulation product (LAP) could be used as a marker of the MHO phenotype in postmenopausal women. A sample of 345 Polish postmenopausal women aged 50-60years old participated in the study. Participants were classified as obese when their BMI was >27. Receiver operating characteristic curve analysis was performed to estimate the best cutoff for the LAP index value to identify postmenopausal women without metabolic syndrome components. We found that the best cutoff value was LAP ≤29.9, and this value was used to define MHO individuals. With this definition, the identification of MHO individuals could be made when both of the following criteria were met: LAP index ≤29.9 and no arterial hypertension (SBP |
| Databáze: | OpenAIRE |
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