The future of fungi: threats and opportunities

Autor: Nicola T Case, Judith Berman, David S Blehert, Robert A Cramer, Christina Cuomo, Cameron R Currie, Iuliana V Ene, Matthew C Fisher, Lillian K Fritz-Laylin, Aleeza C Gerstein, N Louise Glass, Neil A R Gow, Sarah J Gurr, Chris Todd Hittinger, Tobias M Hohl, Iliyan D Iliev, Timothy Y James, Hailing Jin, Bruce S Klein, James W Kronstad, Jeffrey M Lorch, Victoria McGovern, Aaron P Mitchell, Julia A Segre, Rebecca S Shapiro, Donald C Sheppard, Anita Sil, Jason E Stajich, Eva E Stukenbrock, John W Taylor, Dawn Thompson, Gerard D Wright, Joseph Heitman, Leah E Cowen
Přispěvatelé: University of Toronto, Tel Aviv University (TAU), National Wildlife Health Center, Geisel School of Medicine at Dartmouth, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], University of Wisconsin-Madison, Département de Mycologie - Department of Mycology, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Imperial College London, University of Massachusetts System (UMASS), University of Manitoba [Winnipeg], University of California (UC), NTC is supported by a CIHR Canadian Graduate Scholarships—Doctoral award. JH is supported by NIH R01 grants AI39115-24, AI50113-17, and AI133654-05. LEC is supported by CIHR Foundation grant FDN-154288, NIH R01 grants AI127375 and AI120958, and a Canada Research Chair (Tier 1) in Microbial Genomics & Infectious Disease. LKF-L is supported by NIH R35 grant GM143039, NSF CAREER award 2143464, Gordon and Betty Moore Foundation grant #9337, an Excellence in Biomedical Science award from the Smith Family Foundation, and a Pew Scholar award from the Pew Charitable Trust. AS is supported by NIH grants R01AI136735, R37AI066224, R01AI146584, and U19AI166798. CTH is supported by NSF grants DEB-1442148 and DEB-2110403, in part by the DOE Great Lakes Bioenergy Research Center (DOE Office of Science BER DE-FC02-07ER64494), the USDA National Institute of Food and Agriculture (Hatch project 1003258), and an H. I. Romnes Faculty Fellowship from the Office of the Vice Chancellor for Research and Graduate Education with funding from the Wisconsin Alumni Research Foundation. MCF is supported by the Wellcome Trust 219551/Z/19/Z, NERC grant NE/S000844/, and MRC grant MR/R015600/1. RSS is supported by an NSERC Discovery Grant (RGPIN-2018-4914) and a CIHR Project Grant (PJT 162195). TMH is supported by NIH grants R37AI093808, R01AI139632, R21AI156157, and by P30CA008748 (to Memorial Sloan Kettering Cancer Center)., Andrews, B.
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: G3
G3, 2022, 12 (11), pp.jkac224. ⟨10.1093/g3journal/jkac224⟩
G3: Genes, Genomes, Genetics
ISSN: 2160-1836
DOI: 10.1093/g3journal/jkac224⟩
Popis: The fungal kingdom represents an extraordinary diversity of organisms with profound impacts across animal, plant, and ecosystem health. Fungi simultaneously support life, by forming beneficial symbioses with plants and producing life-saving medicines, and bring death, by causing devastating diseases in humans, plants, and animals. With climate change, increased antimicrobial resistance, global trade, environmental degradation, and novel viruses altering the impact of fungi on health and disease, developing new approaches is now more crucial than ever to combat the threats posed by fungi and to harness their extraordinary potential for applications in human health, food supply, and environmental remediation. To address this aim, the Canadian Institute for Advanced Research (CIFAR) and the Burroughs Wellcome Fund convened a workshop to unite leading experts on fungal biology from academia and industry to strategize innovative solutions to global challenges and fungal threats. This report provides recommendations to accelerate fungal research and highlights the major research advances and ideas discussed at the meeting pertaining to 5 major topics: (1) Connections between fungi and climate change and ways to avert climate catastrophe; (2) Fungal threats to humans and ways to mitigate them; (3) Fungal threats to agriculture and food security and approaches to ensure a robust global food supply; (4) Fungal threats to animals and approaches to avoid species collapse and extinction; and (5) Opportunities presented by the fungal kingdom, including novel medicines and enzymes.
Databáze: OpenAIRE
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