Overexpression of Epithelial Cell Adhesion Molecule Antigen in Gallbladder Carcinoma Is an Independent Marker for Poor Survival
| Autor: | Peter Obrist, Guenther Gastl, Mathias Zitt, Dominic Fong, Gilbert Spizzo, Thomas Brunhuber, Meri Varga, Christina Felgel-Farnholz, Stephan Schneeberger, Gilbert Mühlmann, Georg Schäfer |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Biology chemistry.chemical_compound Antigens Neoplasm Biomarkers Tumor Carcinoma medicine Humans Survival analysis Aged Aged 80 and over Univariate analysis Gallbladder Cancer Epithelial cell adhesion molecule Middle Aged Epithelial Cell Adhesion Molecule Prognosis medicine.disease Immunohistochemistry Survival Analysis medicine.anatomical_structure Oncology chemistry Resection margin Cancer research Female Gallbladder Neoplasms Cell Adhesion Molecules |
| Zdroj: | Clinical Cancer Research. 10:3131-3136 |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-03-0528 |
| Popis: | Purpose: Gallbladder carcinoma is an aggressive type of cancer that is difficult to cure by conventional procedures. There thus is a need to identify novel molecular markers for the assessment of prognosis and as potential therapeutic targets. This retrospective study was designed to investigate the prognostic significance of epithelial cell adhesion molecule (Ep-CAM) overexpression in human gallbladder carcinoma. Experimental Design: Ep-CAM expression was examined immunohistochemically on paraffin-embedded tissue specimens from 99 patients who underwent surgical treatment for gallbladder carcinoma in the period between August 1988 and May 1999. Results: Ep-CAM overexpression was found in 63 (63.6%) of the tumor samples. Kaplan-Meier curves showed that Ep-CAM overexpression was significantly related to decreased overall survival (P < 0.01). Overall survival gradually worsened with increasing Ep-CAM scores. Notably, in the subgroup of pT1 tumors (n = 17), patients without Ep-CAM overexpression had a 5-year overall survival rate of 100% compared with 38% (P = 0.01) for patients with Ep-CAM-overexpressing tumors. By univariate analysis, no correlation was found with conventional clinicopathological parameters. Multivariate analysis, including Ep-CAM expression, pT stage, tumor grade, and resection margin involvement, showed that Ep-CAM overexpression was an independent prognostic marker in gallbladder carcinoma (P = 0.03; relative risk, 1.8). Conclusions: These results demonstrate for the first time that Ep-CAM overexpression is an independent prognostic marker in gallbladder carcinoma and that its prognostic impact should be validated prospectively. Furthermore, the Ep-CAM antigen represents an attractive target for specific therapies with monoclonal antibodies or specific vaccines in patients with Ep-CAM-overexpressing gallbladder carcinoma. |
| Databáze: | OpenAIRE |
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