Arsenic intoxication presenting as a myelodysplastic syndrome: a case report
| Autor: | Crawford Anderson, William T. Pastuszak, Stephen R. Conway, William N. Rezuke, Stephen I. Firshein |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Pancytopenia Arsenic poisoning Gastroenterology Arsenic Diagnosis Differential Bone marrow aspirate Bone Marrow Internal medicine Arsenic Poisoning Medicine Humans Arsenic intoxication Marrow cell business.industry Poisoning Hyperesthesia Heavy metals Hematology medicine.disease Myelodysplastic Syndromes Female Differential diagnosis medicine.symptom business |
| Zdroj: | American journal of hematology. 36(4) |
| ISSN: | 0361-8609 |
| Popis: | A case of arsenic intoxication presenting as a myelodysplastic syndrome is reported. A 41-year-old woman with a 6-month history of gastrointestinal and neurological symptoms was noted to be pancytopenic at presentation. A bone marrow aspirate revealed dysmyelopoietic changes involving all three marrow cell lines. Subsequent analysis of urine for heavy metals demonstrated very high levels of arsenic. Treatment with British anti-Lewisite (BAL) resulted in the resolution of gastrointestinal symptoms and hematological abnormalities although the neurological complications progressed. This case emphasizes that heavy metal intoxication should be considered in the differential diagnosis of any individual presenting with the hematological features of myelodysplasia especially when accompanied by clinical features considered atypical for primary or secondary myelodysplasia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text