Renal oncocytosis: a clinicopathological and cytogenetic study of 42 tumours occurring in 11 patients
| Autor: | Enrico Bollito, Michelangelo Fiorentino, Francesco Porpiglia, Simona Vatrano, Riccardo Schiavina, Mauro Papotti, Riccardo Bertolo, Valerio Vagnoni, Elisa Capizzi, Francesca Giunchi, Stefano Tamberi |
|---|---|
| Přispěvatelé: | Giunchi, Francesca, Fiorentino, Michelangelo, Vagnoni, Valerio, Capizzi, Elisa, Bertolo, R, Porpiglia, F, Vatrano, S, Tamberi, S, Schiavina, Riccardo, Papotti, Michela, Bollito, E. |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Angiomyolipoma DNA Copy Number Variations Renal oncocytosi Chromophobe Renal Cell Carcinoma Renal oncocytosis hybrid tumours kidney oncocytoma Biology Kidney urologic and male genital diseases Pathology and Forensic Medicine 03 medical and health sciences Cytokeratin 0302 clinical medicine medicine Adenoma Oxyphilic Humans Oncocytoma Renal oncocytoma Carcinoma Renal Cell In Situ Hybridization Fluorescence Aged Retrospective Studies Aged 80 and over Papillary renal cell carcinomas Middle Aged medicine.disease hybrid tumour Kidney Neoplasms Clear cell renal cell carcinoma 030104 developmental biology medicine.anatomical_structure 2734 030220 oncology & carcinogenesis Female |
| Zdroj: | Pathology. 48:41-46 |
| ISSN: | 0031-3025 |
| Popis: | Renal oncocytosis is a rare pathological condition characterised by the presence of multiple oncocytic tumours with a spectrum of histological features ranging from renal oncocytoma, hybrid oncocytic tumour and rarely chromophobe renal cell carcinoma, sometimes overlapping. Here we retrospectively analysed histological, immunohistochemical (IHC), and cytogenetic features of 42 lesions in 11 patients with renal oncocytosis, not associated with Birt-Hogg-Dubé syndrome. The histology of all the lesions was blindly reviewed by three dedicated genitourinary pathologists. IHC for cytokeratin 7 (CK7) and fluorescence in situ hybridisation (FISH) for copy number variation of chromosomes 1, 6, 7 and 17 were performed in all 42 nodules. Among the 42 lesions 36 (85.7%) were histologically renal oncocytomas, two (4.76%) 'hybrid oncocytic tumours' (HOT), one (2.4%) clear cell renal cell carcinoma (ccRCC), one (2.4%) papillary renal cell carcinoma (pRCC), one typical angiomyolipoma (2.4%), and one mixed epithelial/stromal tumour of the kidney (2.4%). FISH analysis confirmed the histological diagnosis of all the lesions. We show that most patients with renal oncocytosis harbour benign or low malignant potential tumours that can be treated conservatively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect