Both extrauterine and intrauterine growth restriction impair renal function in children born very preterm
Autor: | Brigitte Guy, Isabelle Canterino, Guy Putet, Behrouz Kassai, Jérôme Harambat, Justine Bacchetta, Aurélia Liutkus, Pierre Cochat, Laurence Dubourg |
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Přispěvatelé: | Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS) |
Jazyk: | angličtina |
Rok vydání: | 2009 |
Předmět: |
Male
Pediatrics medicine.medical_specialty [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] iUGR Birth weight 030232 urology & nephrology Intrauterine growth restriction Gestational Age Kidney Cohort Studies perinatal protein intake 03 medical and health sciences 0302 clinical medicine Pregnancy 030225 pediatrics Internal medicine EUGR medicine Birth Weight Humans Prospective Studies Prospective cohort study Growth Disorders Fetal Growth Retardation business.industry prematurity renal function Infant Newborn Gestational age medicine.disease Endocrinology Nephrology Cohort Gestation Female Energy Intake business Infant Premature Follow-Up Studies Glomerular Filtration Rate Cohort study |
Zdroj: | Kidney International Kidney International, Nature Publishing Group, 2009, 76(4), pp.445-452 Kidney International, 2009, 42nd Annual Meeting of the European-Society-for-Paediatric-Nephrology Sep 2008 Lyon, 76 (4), pp.445-452. ⟨10.1038/ki.2009.201⟩ |
ISSN: | 0085-2538 1523-1755 |
Popis: | A single-center prospective cohort study was designed to identify alterations of renal function during childhood in children born prematurely. A cohort of 143 such babies born over a 4-year period (birth weight less than 1000 g and/or less than 30 weeks of gestation) was prospectively included at birth. A mailing was sent to all parents to propose renal evaluation. Among the 50 included children, 23 had intra-uterine and 16 had extrauterine growth retardation. When comparing both of these groups to 11 children with appropriate pre- and postnatal growth at a mean follow-up of 7.6 years, both groups of growth-restricted children had slightly but significantly lower glomerular filtration rates, measured by inulin clearance, although both groups were still within the normal range for their ages. There were no differences for other renal parameters, neonatal therapies or complications, except for postnatal corticosteroid exposure. Children with extrauterine growth restriction were found to have significantly lower protein-energy intake during their first week of life than the intrauterine growth-restricted or the normotrophic children. Our study found that children with either intra- or extrauterine growth retardation are at risk of decreased glomerular filtration rates during childhood. Extrauterine growth restriction represents a new risk factor for long-term renal impairment in premature children. |
Databáze: | OpenAIRE |
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