Domino Asymmetric Conjugate Addition–Conjugate Addition

Autor:	Mathieu F. Chellat, Alexandre Alexakis, Stephane Rosset, Nicolas Germain, Doriane Schlaefli
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Enantiopure drug Chemistry Stereochemistry Yield (chemistry) Organic Chemistry Electrophile ddc:540 Physical and Theoretical Chemistry Biochemistry Combinatorial chemistry Domino Conjugate
Zdroj:	Organic Letters, Vol. 16, No 7 (2014) pp. 2006-2009 ORGANIC LETTERS
ISSN:	1523-7060
Popis:	Enantioenriched Al-, Mg-, and Zn-enolates undergo electrophilic trapping by nitroolefins and vinylsulfones to afford 1,4-diketones and 2-(bis(phenylsulfonyl)ethyl)ketones in good yield and excellent diastereoselectivity. A one-pot preparation of indenes and enantiopure syntheses of tetrahydrobenzofurans, tetrahydrobenzopyrroles, and azulenes are disclosed. A site-selective two-step sequence of three conjugate additions is also demonstrated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf1de43173f3d7537daeed4faf90c45 https://archive-ouverte.unige.ch/unige:35768 Zobrazit plný text záznamu