Novel technologies: A weapon against tuberculosis
| Autor: | N Muthukrishnan, Prabhu Karunakaran, B. Samyuktha Rani, B. N. Vedha Hari, Ramadevi Bhimavarapu, Karuna Priya Chitra |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
Drug medicine.medical_specialty Tuberculosis targeted site medicine.drug_class business.industry media_common.quotation_subject Antibiotics Drug resistance Review Article medicine.disease Drug development tuberculosis Drug delivery medicine Therapeutic failure Nanotechnology Pharmacology (medical) Intensive care medicine business Dosing Frequency polymers media_common |
| Zdroj: | Indian Journal of Pharmacology |
| ISSN: | 1998-3751 0253-7613 |
| Popis: | Tuberculosis (TB) is a leading chronic bacterial infection. Despite potentially curative pharmacotherapies being available for over 50 years, the length of the treatment and the pill burden can hamper patient lifestyle. Low compliance and adherence to administration schedules remain the main reasons for therapeutic failure and contribute to the development of multidrug-resistant strains. The design of novel antibiotics attempts to overcome drug resistance, to shorten the treatment course, and to reduce drug interactions. In this framework, nanotechnology appears as one of the promising approaches for the development of more effective medicines. The present review thoroughly overviews the development of novel microparticulate, encapsulation, and various other carrier-based drug delivery systems for incorporating the principal anti-TB agents. Drug delivery systems have been designed that either target the site of TB or reduce the dosing frequency with the aim of improving patient healthcare. |
| Databáze: | OpenAIRE |
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