Isolation and deisolation of patients admitted with presumptive pulmonary tuberculosis.Can it be shortened?
| Autor: | Abuzaid A. Abuzaid, Fatehi Elzein, Mohammed Mursi, Shoug F. Algoblan, Nisreen Alsherbeeni, Ali Albarrak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Tuberculosis Adolescent Isolation (health care) Saudi Arabia lcsh:Medicine 030204 cardiovascular system & hematology Polymerase Chain Reaction Tertiary care Patient Isolation Mycobacterium tuberculosis Young Adult 03 medical and health sciences 0302 clinical medicine Pulmonary tuberculosis Internal medicine medicine Humans 030212 general & internal medicine Xpert Tuberculosis Pulmonary Aged Retrospective Studies Aged 80 and over biology business.industry smear lcsh:R Sputum Retrospective cohort study General Medicine Middle Aged medicine.disease biology.organism_classification bacterial infections and mycoses tuberculosis Female Original Article medicine.symptom business isolation Rifampicin medicine.drug |
| Zdroj: | Saudi Medical Journal, Vol 40, Iss 10, Pp 1008-1012 (2019) Saudi Medical Journal |
| ISSN: | 1658-3175 0379-5284 |
| Popis: | Objectives: To determine the ideal number of sputum acid-fast bacilli (AFB) smears and polymerase chain reaction (PCR) required for discontinuing TB isolation among patients with suspected pulmonary TB. Methods : This was a single-center, record-based retrospective study of all admitted patients diagnosed with culture-proven pulmonary TB between 2010 and 2018. The study was conducted at Prince Sultan Military Medical City (PSMMC) in Riyadh, Saudi Arabia, a large tertiary care center consisting of 1,200 beds. Data were obtained from our TB notification records. Patients with smear-positive TB were investigated. Only the first 3 sputum smears for AFB were included in the analysis. The PCR results for Mycobacterium tuberculosis (MTB) were also included in the study. The incremental yield of the second and third smears was assessed. Results : Overall, 240 patients were MTB-culture positive. A total of 126 (52.5%) patients were smear and culture positive, whereas 114 were culture positive but smear negative. Of 126 patients who were AFB smear positive, 98 (77.8%) were detected in the first specimen, 13 (10.3%) in the second specimen, and only 9 (7.1%) in the third specimen. Polymerase chain reaction for MTB was positive in 122 (96.8%) smear-positive patients. Four patients did not undergo a PCR test. Conclusion : A single Xpert MTB/resistance to rifampicin test detected all smear-positive patients, whereas the third smear did not significantly contribute to MTB isolation. Saudi Med J 2019; Vol. 40 (10): 1008-1012 doi: 10.15537/smj.2019.10.24564 How to cite this article: Elzein FE, Alsherbeeni N, Mursi M, Algoblan SF, Abuzaid AA, Albarrak AM. Isolation and deisolation of patients admitted with presumptive pulmonary tuberculosis. Can it be shortened? Saudi Med J 2019; 40: 1008-1012. doi: 10.15537/smj.2019.10.24564 |
| Databáze: | OpenAIRE |
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